Results 101 to 110 of about 1,914,645 (291)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Quasar Tomography: Unification of Echo Mapping and Photoionisation Models

, 2002
Reverberation mapping uses time-delayed variations in photoionised emission lines to map the geometry and kinematics of emission-line gas in active galactic nuclei.
Goad, Michael R, Horne, Keith, Korista, Kirk T   +2 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A high-density linkage map and fine QTL mapping of architecture, phenology, and yield-related traits in faba bean (Vicia faba L.)

Frontiers in Plant Science
Faba bean is a key protein feed and food worldwide that still requires accurate genomic tools to facilitate molecular marker-assisted breeding. Efficient quantitative trait locus (QTL) mapping in faba bean is restricted by the low or medium density of ...
David Aguilar-Benitez, Natalia Gutierrez, Inés Casimiro-Soriguer, Ana M. Torres   +3 more
doaj   +1 more source

A high density linkage map of the bovine genome

BMC Genetics, 2009
Background Recent technological advances have made it possible to efficiently genotype large numbers of single nucleotide polymorphisms (SNPs) in livestock species, allowing the production of high-density linkage maps.
Coppieters Wouter, Fisher Paul, Keehan Mike, Arias Juan A, Spelman Richard   +4 more
doaj   +1 more source

Structural Order in Glassy Water

, 2005
We investigate structural order in glassy water by performing classical molecular dynamics simulations using the extended simple point charge (SPC/E) model of water.
C. Kittel, Francesco Sciortino, H. Eugene Stanley, Nicolas Giovambattista, O. Mishima, P. G. Debenedetti, Pablo G. Debenedetti, R. Zallen, S. Torquato   +8 more
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A High-Density Genetic Map for Cucumber (Cucumis Sativus L.) Based on Specific Length Amplified Fragment (SLAF) Sequencing and QTL Analysis of Fruit Traits in Cucumber

Frontiers in Plant Science, 2016
High-density genetic linkage map plays an important role in genome assembly and QTL fine mapping. Since the coming of next-generation sequencing (NGS), makes the structure of high-density linkage maps much more convenient and practical, which simplifies ...
Wenying eZhu, Long eHuang, Long eChen, Jiantao eYang, Jiani eWu, Meiling eQu, Danqing eYao, Chunli eGuo, Hongli eLian, Huanle eHe, Junsong ePan, Run eCai   +11 more
doaj   +1 more source

Numerical estimate of infinite invariant densities: application to Pesin-type identity

, 2013
Weakly chaotic maps with unstable fixed points are investigated in the regime where the invariant density is non-normalizable. We propose that the infinite invariant density of these maps can be estimated using as the long time limit of t^(1-alpha) rho(x,
Barkai, Eli, Korabel, Nickolay
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source