Results 51 to 60 of about 511,382 (289)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Comprehensive Splice Pattern Analysis for Previously Reported OCRL Splicing Variants and Their Phenotypic Contributions

Kidney International Reports
Introduction: Two distinct phenotypes of Dent disease-2 and Lowe syndrome are caused by oculocerebrorenal syndrome of Lowe (OCRL) abnormality. Previous genetic studies demonstrated that truncating variants in exons 1 to 7 results in Dent disease-2 and in
Rini Rossanti, Eri Okada, Nana Sakakibara, Ryota Suzuki, Yuta Inoki, Yuta Ichikawa, Yu Tanaka, Hideaki Kitakado, Chika Ueda, Atsushi Kondo, Yuya Aoto, China Nagano, Tomoko Horinouchi, Tomohiko Yamamura, Shingo Ishimori, Kandai Nozu   +15 more
doaj   +1 more source

From Skin to Kidneys: The Cutaneous Clues of Renal Disease in Children

Dermatology Practical & Conceptual, 2020
Background:  The skin is often seen as a world apart, but not rarely do cutaneous manifestations reveal signs of systemic disease. Objectives: The aim of this review is to include in one paper all the possible correlations between nephrological and ...
Mario Diplomatico, Pierluigi Marzuillo, Angela La Manna, Andrea Apicella, Stefano Guarino, Vincenzo Piccolo   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Pediatric Dent disease presenting with rickets and end-stage renal disease: case report and literature review

Journal of International Medical Research
Dent disease is a rare disease with proximal renal tubular dysfunction, and is characterized by low-molecular-weight proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis, and chronic kidney disease. Renal failure slowly progresses and end-stage
Youying Mao, Chenxing Zhang, Zhengyu Zhou, Wei Zhou, Lei Yin   +4 more
doaj   +1 more source

Management of Cracked tooth syndrome: A case Report

Update Dental College Journal, 2014
Cracked tooth is a distinct type of longitudinal tooth fracture which occurs very commonly and its diagnosis can be challenging. This type of fracture tends to grow and change over time. Clinical diagnosis is difficult because the signs and symptoms are
AHM Zakir Hossain Shikdera, SM Abdul Quader, Shirin Sultana Chowdhury, Ferdousi Begum, Md Nazmul Hasan   +4 more
doaj   +1 more source

Exposure to the Dental Environment and Prevalence of Respiratory Illness in Dental Student Populations [PDF]

, 2004
Objective: To determine if the prevalence of respiratory disease among dental students and dental residents varies with their exposure to the clinical dental environment.
Chen, Casey, Dentino, Andrew R., DiTolla, Maris, Ho, Alex W., Scannapieco, Frank A.   +4 more
core   +1 more source

Prevalence of halitosis and evaluation of etiological factors in a Turkish subpopulation [PDF]

, 2016
Aim: The purpose of this study was to estimate the prevalence of halitosis in an adult Turkish subpopulation and to assess the relationship between halitosis and sociodemographics, self reported halitosis, etiological factors, by employing standardized ...
Güngör, Kahraman, Yıldızer Keri̇ş, Eli̇f, Özdede, Meli̇h, Özütürk, Özge   +3 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Dent disease

Zdravniški Vestnik, 2017
Dent disease is an x-linked disorder of proximal renal tubular dysfunction that occurs almost exclusively in males. It is characterized by significant, mostly low molecular weight proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis, and ...
Rina R Rus, Kristina Vogrin
doaj