Results 101 to 110 of about 158,566 (316)

Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall   +3 more
wiley   +1 more source

The Influence of Stress and Anxiety on the Expectation, Perception and Memory of Dental Pain in Schoolchildren

open access: yesDentistry Journal, 2018
The aim of this study was to investigate the association of stress and anxiety with the expectation, perception and memory of dental pain among schoolchildren. A follow-up study involving 46 children aged 9 to 12 years was conducted in a public school in
Gabriela de A. Lamarca   +2 more
doaj   +1 more source

Grading the intensity of nondental orofacial pain: Identification of cutoff points for mild, moderate, and severe pain [PDF]

open access: yes, 2015
Background: When assessing pain in clinical practice, clinicians often label pain as mild, moderate, and severe. However, these categories are not distinctly defined, and are often used arbitrarily.
Brailo, V, Zakrzewska, JM
core   +2 more sources

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

open access: yesEpilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira   +5 more
wiley   +1 more source

Are left-handers really more anxious? [PDF]

open access: yes, 2012
Research examining anxiety and handedness is inconclusive. Davidson and Schaffer (1983) found left-handers had higher trait anxiety, while Beaton and Moseley (1991) found no state or trait differences. Such studies potentially have methodological issues,
Hardie, Scott M., Wright, Lynn
core   +3 more sources

Leptin Reduces Running in a Rodent Anorexia Nervosa Model via a Distributed Neural Network

open access: yesEuropean Eating Disorders Review, EarlyView.
ABSTRACT Objective Hyperactivity is a persistent and clinically relevant symptom in anorexia nervosa (AN). Hyperactivity is inversely correlated with leptin levels. While systemic leptin administration attenuates hyperactivity in rodent models, the specific brain regions mediating this effect remain unclear.
Nick J. M. Papavoine   +6 more
wiley   +1 more source

Dental anxiety: a comparison of students of dentistry, biology, and psychology

open access: yesJournal of Multidisciplinary Healthcare, 2014
Helene Persen Storjord,1 Mari Mjønes Teodorsen,1 Jan Bergdahl,1 Rolf Wynn,2,3 Jan-Are Kolset Johnsen1 1Department of Clinical Dentistry, 2Department of Clinical Medicine, UiT - The Arctic University of Norway, 3Division of Addictions and ...
Storjord HP   +4 more
doaj  

Exploring dental anxiety as a mediator in the relationship between mindfulness or self-compassion and dental neglect

open access: yesHeliyon
Dental anxiety and dental neglect are interconnected constructs with profound consequences for oral health and corresponding challenges for dental professionals.
Charalampos Beltes   +2 more
doaj   +1 more source

Elimination of pain improves specificity of clinical diagnostic criteria for adult chronic rhinosinusitis [PDF]

open access: yes, 2017
Objective Determine whether the elimination of pain improves accuracy of clinical diagnostic criteria for adult chronic rhinosinusitis. Study Design Retrospective cohort study.
DiNardo, Laurence J.   +4 more
core   +2 more sources

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

open access: yesInterdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi   +13 more
wiley   +1 more source

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