Results 71 to 80 of about 2,245 (285)

Design, synthesis, molecular docking and cytotoxic evaluation of novel pyrimidine-based sulfonamide derivatives as potent anticancer agents: SAR insights and biological profiling

open access: yesScientific Reports
The low selectivity and significant toxicity of current chemotherapeutic medicines make the research and development of novel anticancer agents an urgent necessity.
Nesma M. Bayoumy   +3 more
doaj   +1 more source

Class II subdivision correction with clear aligners using intermaxilary elastics

open access: yesProgress in Orthodontics, 2018
Background To describe an esthetic orthodontic treatment using aligners in an adult patient with class II subdivision associated with crowding and dental crossbite.
Luca Lombardo   +4 more
doaj   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto   +20 more
wiley   +1 more source

Dental Fear and Anxiety in Children and Adolescents: Qualitative Study Using YouTube

open access: yesJournal of Medical Internet Research, 2013
BackgroundDental fear and anxiety (DFA) refers to the fear of and anxiety towards going to the dentist. It exists in a considerable proportion of children and adolescents and is a major dilemma in pediatric dental practice.
Gao, Xiaoli   +4 more
doaj   +1 more source

Factors Associated with Fissure Sealant Delegation: Dentist Characteristics and Office Staffing Patterns

open access: yes, 1993
The purpose of this research was to identify dentist characteristics and dental office staffing patterns related to delegation of sealant applications. Results from a 1989 ma/led survey were used to characterize Michigan general dentists (N =300) who did
Susan J. Pritzel   +11 more
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

open access: yesAdvanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng   +8 more
wiley   +1 more source

Dental health awareness and practice among secondary school children in Enugu, Nigeria

open access: yesInternational Journal of Medicine and Health Development, 1997
A cross sectional survey of 391 secondary school student was carried out in 1992 to study their dental health knowledge and practice. Their predominant method of cleaning the teeth was the brush method (84%) followed by the traditional chewing stick (45%)
Etisiobi Ndokwelu
doaj  

The acceptability of care provided by dental auxiliaries:A systematic review [PDF]

open access: yes, 2016
BackgroundDental auxiliaries undertaking a limited range of intraoral clinical procedures normally performed by dentists could increase access to care and control costs, yet their acceptability to patients has been questioned.
Robinson, Peter G, Dyer, Thomas A.
core   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

open access: yesAdvanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang   +3 more
wiley   +1 more source

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