Results 241 to 250 of about 77,590 (302)
Epilepsia, EarlyView.Abstract Objective Memory problems are comorbid with temporal lobe epilepsy (TLE). Animal models of TLE reveal impairments in spatial firing fields of hippocampal place cells, providing a potential neural substrate for memory problems. Each subfield of the hippocampus carries out unique aspects of spatial memory, yet little is known about how ...
Brittney L. Boublil +4 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira +5 more
wiley +1 more source
The multiple hit model of infantile and epileptic spasms: The 2025 update
Epilepsia Open, EarlyView.Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou +6 more
wiley +1 more source
Epilepsy surgery: From bench to the clinics
Epilepsia Open, EarlyView.Abstract Objective Recent advances in epilepsy surgery in patients with intractable epilepsy make it possible to study the mechanism of epilepsy in human brains. However, the true extent and propagation of each epileptogenic area from the epileptogenic focus in each patient is still difficult to perform “epilepsy cure” by surgery.
Tatsuya Tanaka
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Objective The pathogenesis of epilepsy is closely associated with neuronal synaptic plasticity. MicroRNAs (miRNAs) can regulate various biological processes by binding to specific sequences on target genes. This study employs bioinformatics, molecular dynamics, and experimental approaches to investigate the mechanism by which MiR‐30a‐5p treats
Zhenlin Yang +4 more
wiley +1 more source
Leptin Reduces Running in a Rodent Anorexia Nervosa Model via a Distributed Neural Network
European Eating Disorders Review, EarlyView.ABSTRACT Objective Hyperactivity is a persistent and clinically relevant symptom in anorexia nervosa (AN). Hyperactivity is inversely correlated with leptin levels. While systemic leptin administration attenuates hyperactivity in rodent models, the specific brain regions mediating this effect remain unclear.
Nick J. M. Papavoine +6 more
wiley +1 more source
Exploration, EarlyView.Amphibian‐derived peptide RL‐QN15 activates the Wnt/β‐catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing.
Yuansheng Li +15 more
wiley +1 more source
Advanced flexible brain computer interface materials: From development to application
FlexMat, EarlyView.This review explores how novel materials coatings are advancing brain‐computer interface (BCI) technology. It describes how these materials help overcome key challenges in signal accuracy, biocompatibility, and device durability. The paper highlights BCI applications in medicine and entertainment, and discusses future trends that could transform human ...
Renquan Guan +5 more
wiley +1 more source
Head &Neck, EarlyView.ABSTRACT Background Simultaneous reconstruction of extensive maxillary and mandibular defects in oncological cases is a complex surgical challenge. Methods We report a case of a 56‐year‐old female with synchronous oral malignancy involving upper and lower alveolus.
Subhendu Khan +3 more
wiley +1 more source