Results 161 to 170 of about 661,666 (348)
Advanced Science, EarlyView.Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang +7 more
wiley +1 more source
Potential biomedical applications of ion beam technology [PDF]
Electron bombardment ion thrusters used as ion sources have demonstrated a unique capability to vary the surface morphology of surgical implant materials.
Babbush, C. A. +3 more
core +1 more source
Advanced Science, EarlyView.We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin +17 more
wiley +1 more source
Susceptibility of selected tooth‐coloured dental materials to damage by common erosive acids [PDF]
, 2008 WZ Wan Bakar, J. McIntyre
openalex +1 more source
Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound
Advanced Science, EarlyView.In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He +8 more
wiley +1 more source
Advanced Science, EarlyView.Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li +9 more
wiley +1 more source