Results 201 to 210 of about 12,770 (234)

Detection of Tumor Necrosis Factor α in Normal and Inflamed Human Dental Pulps

Archives of Medical Research, 2002
The aim of this study was to determine concentrations of tumor necrosis factor-alpha (TNF-alpha) in normal, painful, and asymptomatic human dental pulps.Pulps were obtained from three groups of teeth, including healthy teeth, asymptomatic teeth with caries and/or large restoration, and symptomatic teeth with clinical diagnosis of irreversible pulpitis.
Anić, Ivica, Pezelj-Ribarić, Sonja, Šimunović-Šoškić, Marica, Brekalo Pršo, Ivana, Hasan, Milena, Miletić, Ivana   +5 more
openaire   +3 more sources

Characterization of a programmed necrosis process in 3‐dimensional cultures of dental pulp fibroblasts

International Endodontic Journal, 2012
AbstractAimTo analyse and compare the expression of nemosis markers in human lung and dental pulp fibroblasts and to determine whether this process differs by the type of mesenchymal cell.MethodsHuman dental pulp fibroblasts were obtained from unerupted third molars. Sound lung and pulpal fibroblasts were cultured in vitro as spheroids to determine the
Le Clerc, Justine, Perard, M., Pellen-Mussi, P., Novella, A., Tricot-Doleux, S., Jeanne, Sylvie, Perez, Fabienne   +6 more
openaire   +2 more sources

Early detection of pulp necrosis and dental vitality after traumatic dental injuries in children and adolescents by 3-Tesla magnetic resonance imaging

Journal of Cranio-Maxillofacial Surgery, 2015
More than 50% of all children suffer a traumatic dental injury (TDI) during childhood. In many cases, dentists apply root canal treatment (RCT), which is performed on an average of 7-10 days after replantation. Our aim was to evaluate whether RCT is necessary in many cases, and whether revitalization of affected teeth is possible and measurable by ...
Alexandre T. Assaf, Tomislav A. Zrnc, Chressen C. Remus, Arun Khokale, Christian R. Habermann, Dirk Schulze, Jens Fiehler, Max Heiland, Jan Sedlacik, Reinhard E. Friedrich   +9 more
openaire   +3 more sources

General Control Nonrepressed Protein 5 Modulates Odontogenic Differentiation Through NF-κB Pathway in Tumor Necrosis Factor-α-Mediated Impaired Human Dental Pulp Stem Cells

Cellular Reprogramming, 2022
Dental pulp stem cells (DPSCs) from pulpitis patients showed defective osteogenic differentiation. However, as the most well-studied histone acetyltransferase, the impaired general control nonrepressed protein 5 (GCN5) plays essential roles in various developmental processes.
Jingwen Xiao, Ya Zheng, Wei Zhang, Ye Zhang, Peipei Cao, Yi Liang, Liuliu Bao, Suping Shi, Xingmei Feng   +8 more
openaire   +2 more sources

Hypoxia‐inducible factor 1α promotes interleukin 1β and tumour necrosis factor α expression in lipopolysaccharide‐stimulated human dental pulp cells

International Endodontic Journal, 2020
AbstractAimTo elucidate the role of HIF1α in pro‐inflammatory cytokine mRNA expression from lipopolysaccharide (LPS)‐stimulated human dental pulp cells (hDPCs).MethodologymRNA expression of interleukin (IL) 1β and tumour necrosis factor (TNF) α in LPS‐stimulated hDPCs was determined by quantitative RT‐PCR.
M. Fujii, N. Kawashima, K. Tazawa, K. Hashimoto, K. Nara, S. Noda, S. Nagai, T. Okiji   +7 more
openaire   +2 more sources

Stimulation of Plasminogen Activator Activity and Matrix Metalloproteinases of Human Dental Pulp–Derived Cells by Tumor Necrosis Factor–α

Journal of Endodontics, 2001
The effects of tumor necrosis factor (TNF)-alpha on the plasminogen activator (PA)/plasmin system in human dental pulp (HDP) cells were examined. TNF-alpha treatment induced a significantly high level of PA activity in the conditioned medium of HDP cells in a time- and dose-dependent manner, compared with untreated control cells.
L, Ueda, K, Matsushima
openaire   +2 more sources

Bradykinin and thrombin synergistically potentiate interleukin 1 and tumour necrosis factor induced prostanoid biosynthesis in human dental pulp fibroblasts

Cytokine, 1996
The effects of and interactions between the six inflammatory mediators interleukin-1 (IL-1), tumour necrosis factor (TNF), gamma-interferon (INF-gamma), transforming growth factor-beta (TGF-beta), bradykinin (BK) and thrombin on prostanoid biosynthesis in primary cultures of human, dental, pulp fibroblasts were examined.
G, Sundqvist, U H, Lerner
openaire   +2 more sources

Semaphorin3A released from human dental pulp cells inhibits the increase in interleukin‐6 and CXC chemokine ligand 10 production induced by tumor necrosis factor‐α through suppression of nuclear factor‐κB activation

Cell Biology International, 2020
AbstractHuman dental pulp cells (HDPCs) play an important role in pulpitis. Semaphorin3A (Sema3A), which is an axon guidance molecule, is a member of the secretory semaphorin family. Recently, Sema3A has been reported to be an osteoprotective factor and to be involved in the immune response.
Satoru Shindo, Tomoki Kumagai, Satomi Shirawachi, Katsuhiro Takeda, Hideki Shiba   +4 more
openaire   +2 more sources

Induction of Dental Pulp Fibroblast Matrix Metalloproteinase–1 and Tissue Inhibitor of Metalloproteinase–1 Gene Expression by Interleukin–1α and Tumor Necrosis Factor–α Through a Prostaglandin–Dependent Pathway

Journal of Endodontics, 2001
Matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) are involved in the degradation of extracellular matrix in many inflammatory diseases. Little is known regarding the expression of these mediators in dental pulp fibroblasts. The effects of proinflammatory cytokines (interleukin (IL)-1alpha and tumor necrosis factor-
S K, Lin, C C, Wang, S, Huang, J J, Lee, C P, Chiang, W H, Lan, C Y, Hong   +6 more
openaire   +2 more sources

CAN RADIOTHERAPY CAUSE DENTAL PULP NECROSIS? A SYSTEMATIC REVIEW AND META-ANALYSIS

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2022
Bruna Barcelos Só, Theodoro Weissheimer, Marieli Chitolina Pradebon, José Antônio Poli De Figueiredo, Marcus Vinícius Reis Só, Manoela Domingues Martins   +5 more
openaire   +1 more source