Results 191 to 200 of about 6,028,836 (265)

Human dental pulp mesenchymal stem cells regenerative potential

Background: Stem cells can be divided into mono-potent, oligopotent, multipotent, pluripotent, and totipotent. Dental and oral stem cells are stem cells found in the teeth and mouth that has the potential to develop into various cell types.
Agustin Wahjuningrum, Dian, Ohara, Masaru, Bin Zainal Abidin, Imran, Fadiyan Amriel, Menza, Natan, Daniel, Suardita, Ketut, Auzan Fepiosandi, Radixtio, Priyo Prasetyo, Eric, Zora, Zofia   +8 more
core  

Regenerative Endodontic Procedure in Mandibular First Molar: A Clinical Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Regenerative endodontic procedures (REPs) have emerged as a biologically based treatment modality for managing immature permanent teeth with necrotic pulp, offering the potential for continued root development and periapical healing. This case report describes the regenerative endodontic treatment of a necrotic, immature mandibular first molar
Sorour Saeedi, Ali Hamedi, Mani Mansouri, Iman Shiezadeh   +3 more
wiley   +1 more source

Long‐Term Clinical and Radiographic Outcomes of Large Periapical Lesions Managed by Non‐Surgical and Surgical Endodontic Treatment: A Case Series

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT The management of large periapical lesions is challenging, as lesion size alone does not predict treatment outcome or mandate surgery. This case series presents three large periapical lesions with 4‐ to 12‐year follow‐up, illustrating different therapeutic pathways.
Mohsen Aminsobhani, Maryam Babaahmadi, Razieh Amiri, Maryam Habibzadeh, Nazanin Kamali   +4 more
wiley   +1 more source

Stem Cell and EV/sEV Strategies for Neuroimmune Niche Reprogramming in Selected CNS Disorders: Mechanisms, Engineered Delivery, and Translational Readiness

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Stem cell‐ and EV/sEV‐based interventions may reprogram the CNS neuroimmune niche by suppressing glial inflammation, enhancing trophic and synaptic support, stabilizing BBB communication, and improving metabolic resilience. Clinical translation will require mechanism‐linked potency assays, MISEV‐aligned EV reporting, biodistribution, GMP manufacturing,
Wenjing Lu, Junqiang Yan, Hongfang Feng
wiley   +1 more source

Effect of Root Canal Dressings on Extraradicular pH in a Sealed Apex Model: An In Vitro Study

Clinical and Experimental Dental Research, Volume 12, Issue 5, October 2026.
ABSTRACT Objectives Endodontic treatment is mandatory after severe dental trauma such as avulsion or intrusion. Initial intracanal dressing with calcium hydroxide should be avoided according to international guidelines due to potential periodontal ligament damage by pH elevation.
Alina Paganini, Eva Magni, Wadim Leontiev, Thomas Connert, Anne Géraldine Guex, Andreas Filippi   +5 more
wiley   +1 more source

Multifunctional Hydrogels: Rational Design and Application in Regenerative Medicine

MedComm, Volume 7, Issue 10, October 2026.
Multifunctional hydrogels represent a paradigm shift in regenerative medicine, integrating rational material design with bioactive functionality to address complex tissue repair challenges. This review systematically examines the molecular engineering, structure–function relationships, and translational landscape of advanced hydrogel systems, spanning ...
Linyang Song, Epiphane K. Silli, Yazhen Xu, Huixia Lv, Ruoxian Song   +4 more
wiley   +1 more source

Carbon Quantum Dots: From Mechanisms to Biomedical Applications

MedComm, Volume 7, Issue 10, October 2026.
Carbon quantum dots (CQDs) are promising carbon‐based nanomaterials with broad biomedical applications, including bioimaging, drug delivery, biosensing, and tissue regeneration. This Review summarizes the biological mechanisms of CQDs in tissue regeneration, focusing on their regulation of cellular functions, immune responses, and redox balance.
Bingxin Fan, Nianqiang Jin, Nuo Jin, Jiayu Shen, Xinliang Duan, Sichen Han, Yao Yuan, Zilin Wang   +7 more
wiley   +1 more source

Optimal Hypoxia Mimetic Small Molecules for Enhancing Angiogenic Properties of Stem Cells From Human Exfoliated Deciduous Teeth

International Endodontic Journal, Volume 59, Issue 10, Page 2122-2142, October 2026.
ABSTRACT Aim Hypoxic preconditioning of cells holds promise for regenerative therapies, yet identifying effective and safe methods for clinical application remains challenging. We aimed to determine optimal hypoxia‐mimetic small molecules (SMs) that stabilize hypoxia‐inducible factor‐1α (HIF‐1α) and their dosages for hypoxic preconditioning in stem ...
Hong Wang, Jiawei Liu, Xintao Yang, Mohamad Koohi‐Moghadam, Shuting Gao, Yuanyuan Han, Dineshi Sewvandi Thalakiriyawa, James Kit Hon Tsoi, Yanqi Yang, Waruna Lakmal Dissanayaka   +9 more
wiley   +1 more source

Biocompatibility of carbazochrome sodium sulfonate on human dental pulp stem cells: An <i>in vitro</i> investigation. [PDF]

J Conserv Dent Endod
Keerthika MR, Surendran S, Natanasabapathy V, Chandrasekaran S, Vasudevan A, Baskar K.   +5 more
europepmc   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, Volume 59, Issue 10, Page 2028-2045, October 2026.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source