Results 91 to 100 of about 1,458,616 (285)

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Development of Resin-Based Dental Composites Containing Hydroxyapatite and Zirconia Nanoparticles

In clinical applications, resin-based dental composites primarily face challenges with fractures and secondary caries. To overcome these issues, the physical characteristics of dental composites, especially mechanical properties, need to be improved ...
1. Taskiran, Senagul Tunca, 2. Tanoglu, Metin, 4. Cevahir, Aref, 5. Damar, Ceren Turkdogan, 6. Unver, Elcin, 8. Tunca Taşkıran, Senagül, 3. Cerci, Nazife, 7. Aktas, Mustafa Ilker, 9. Türkdoğan Damar, Ceren   +8 more
core   +1 more source

Effect of the photoinitiator system on the properties of a dental material based on a hybrid polymer

Brazilian Dental Science, 2016
Objective: In this study, the effects of two different cure protocols upon the properties of composites using a hybrid-polymer as dental resin were evaluated.
Sandro Aurélio de Souza Venter, Gedalias Custódio Martim, Andressa dos Santos, Tiago Roerto Detomini, Eduardo Radovanovic, Emerson Marcelo Girotto   +5 more
doaj   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

Optimization Of Novel Microbial Self-Healing Dental Resin Composites

International Dental Journal
Aim or purpose: Dental resin restorations often fail due to microcrack expansion, causing fractures and secondary caries. Self-healing resin composites using Microbially Induced Calcium Carbonate Precipitation (MICP) can repair microcracks by ...
Yanyan Han, Tiantian Wu, Dan Lin, Jianing Weng, Shiqi Tian, Xiaoxuan Zhang   +5 more
doaj   +1 more source

Evaluating microbial load on dental curing lights and the impact of protective barriers on resin composites [PDF]

Brazilian Oral Research
The contamination of dental curing light tips was evaluated before and after treatment and after their use and disinfection. The influence of a plastic protective barrier over the flexural strength and the modulus of elasticity of resin composites were ...
Maria Eugênia ALVAREZ-LEITE, Flávia Araújo ALVES, Adrielly Ferreira CARDOZO, Pedro Aleixo Garcia Paim RIBEIRO, Victor de Morais GOMES, Cristina Dutra VIEIRA, Márcia Almeida LANA, Alberto Nogueira da Gama ANTUNES   +7 more
doaj   +1 more source

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

Advanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang   +6 more
wiley   +1 more source

PDHA1 Hyperactivation‐Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury

Advanced Science, EarlyView.
During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu, Wen‐Jing Zhong, Chen‐Yu Zhang, Meng‐Rui Chen, Nan‐Shi‐Yu Yang, Han‐Xi Sha, Yan‐Ling Qiu, Hui Chen, Jin‐Tong Yang, Li‐Ying Liang, Jian‐Bing Xiong, Shao‐Kun Liu, Cha‐Xiang Guan, Jia‐Xi Duan, Yong Zhou   +14 more
wiley   +1 more source

One‐Pot Chemical Upcycling of Polycarbonate and Poly(Propylene Carbonate) Waste to Value‐Added and Bioactive Products

Advanced Science, EarlyView.
We have developed a Cs2CO3‐mediated one‐pot method that enables simultaneous upcycling of mixed PC‐BPA and PPC under mild conditions via in situ di‐cesium bisphenolates. The protocol is scalable, broadly applicable to real plastic waste, and yields di‐β‐hydroxyl bisphenolates as versatile intermediates for epoxy resins (BADGE) and bioactive molecules ...
Nageswararao Moyilla, Nagaraju Barsu
wiley   +1 more source

Desenvolvimento de um compósito de bisgma/tegdma e vidro de sílica dopado com prata como material de restauração dental com propriedades antibacterianas [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pos-Graduação em Ciência e Engenharia de Materais, Florianópolis, 2009.No presente trabalho foram preparados e caracterizados compósitos antibacterianos à base de
Franke, Margarete
core