Results 121 to 130 of about 50,286 (298)

Loss of intraflagellar transport 140 in osteoblasts cripples bone fracture healing

open access: yesFundamental Research
The indispensability of primary cilia in skeletal development has been widely recognized. We have previously shown that intraflagellar transport 140 (IFT140), a protein component of a bidirectional intraflagellar transport system required for ciliary ...
Qiqi Fan   +8 more
doaj   +1 more source

Sleep Deprivation Activates a Conserved Lactate‐H3K18la‐RORα Axis Driving Neutrophilic Inflammation Across Species

open access: yesAdvanced Science, EarlyView.
Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou   +15 more
wiley   +1 more source

Multifunctional human serum albumin-crosslinked and self-assembling nanoparticles for therapy of periodontitis by anti-oxidation, anti-inflammation and osteogenesis

open access: yesMaterials Today Bio
Periodontitis is a chronic inflammatory disease that can result in the irreversible loss of tooth-supporting tissues and elevate the likelihood and intensity of systemic diseases.
Bangping Cao   +9 more
doaj   +1 more source

Macrophage Derived Galectin‐3 Promotes Renal Fibrosis and Diabetic Kidney Disease by Enhancing TGFβ1 Signaling

open access: yesAdvanced Science, EarlyView.
Macrophage‐derived Galectin‐3 amplifies TGFβ1 signaling to drive diabetic kidney fibrosis: a novel therapeutic target. Abstract Over 30% of patients with type 2 diabetes develop diabetic kidney disease (DKD), which has emerged as a major contributor to end stage renal disease.
Yibing Chen   +17 more
wiley   +1 more source

Effect of 3D-printing assisted micro-osteoperforations on the rate of canine retraction: a clinical investigation

open access: yesBMC Oral Health
Objectives More time is often needed for adult orthodontic patients compared with juvenile counterparts due to lower tissue vitality. In some cases, the prolonged orthodontic treatment may cause a series of problems, such as enamel demineralization ...
Yangyifan Zhou   +5 more
doaj   +1 more source

Reasons for replacement of restorations in permanent teeth in general dental practice

open access: bronze, 2000
Ivar A. Mjör   +2 more
openalex   +1 more source

Restoration of Occlusal Vertical Dimension in Dental Erosion Caused by Gastroesophageal Reflux: Case Report [PDF]

open access: bronze, 2010
Eduardo Galia Reston   +4 more
openalex   +1 more source

Engineered Dual‐Function Antibody‐Like Proteins to Combat SARS‐CoV‐2‐Induced Immune Dysregulation and Inflammation

open access: yesAdvanced Science, EarlyView.
Engineered antibody‐like proteins block the SARS‐CoV‐2 spike protein from binding to host receptors and suppress immune overactivation through an MBL‐based scaffold. These dual‐function proteins effectively alleviate inflammation, complement activation, and lung injury, offering a promising therapeutic strategy against severe COVID‐19 and its ...
Yizhuo Wang   +7 more
wiley   +1 more source

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