Results 131 to 140 of about 144,484 (342)

PVC Nanoplastics Exposure Exacerbates Asthma through R‐Loop Accumulation and Subsequent STING Activation in Macrophages

open access: yesAdvanced Science, EarlyView.
Polyvinyl chloride (PVC) nanoplastics (NPs) are shown to aggravate allergic airway inflammation in asthma by triggering R‐loop accumulation and activating the cGAS‐STING pathway in macrophages. This study reveals a novel immunotoxic mechanism linking environmental plastic exposure to asthma pathogenesis and highlights potential molecular targets for ...
Qimei Bao   +16 more
wiley   +1 more source

THE USE OF CAD/CAM TECHNOLOGIES IN MINIMALLY INVASIVE DENTAL RESTORATIONS: A SYSTEMATIC REVIEW

open access: yesRomanian Journal of Oral Rehabilitation
Aim of the study The study reviews dental treatment effectiveness, CAD/CAM technology compatibility, and restorative materials’ clinical performance, focusing on demographics, criteria, interventions, methodologies, and outcomes across countries and ...
Nadiia Melnyk   +4 more
doaj   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

open access: yesAdvanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin   +14 more
wiley   +1 more source

NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex

open access: yesAdvanced Science, EarlyView.
The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang   +8 more
wiley   +1 more source

The Effect of Dental Implant Restoration on the Biomechanics of the Temporomandibular Joint in Patients with Posterior Tooth Loss: A Pilot Study

open access: yesBioengineering
Currently, controversy persists over whether dental implant restoration exacerbates or alleviates temporomandibular disorders (TMDs). This study aimed to analyze the impact of dental implant restoration on the biomechanics of the temporomandibular joint (
Yuanli Zhang   +8 more
doaj   +1 more source

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