Sepsis‐associated acute kidney injury is driven by oxidative stress, NETs overproduction, and dysregulated innate immunity. Here, we develop neutrophil‐mimetic nanoscavengers that integrate ROS‐scavenging Mn3O4 nanozymes with DNase‐1‐mediated NETs degradation to suppress cGAS‐STING signaling, reprogram macrophage polarization, and effectively alleviate
Zening Zhang +9 more
wiley +1 more source
Mechanical properties and formulation of hydrophilic fiber and shrimp shell combination as a novel eco-friendly dental restoration material. [PDF]
Fadhila DN +6 more
europepmc +1 more source
The motivational effect of multicolored dental restoration on dental behavior of first preliminary school children. [PDF]
Melebari LA, Attas SE, Arafa A.
europepmc +1 more source
Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi +4 more
wiley +1 more source
Comparative Assessment of the Influence of Various Time Intervals upon the Linear Accuracy of Regular, Scannable, and Transparent Vinyl Polysiloxane-Based Bite Registration Materials for Indirect Dental Restoration Fabrication. [PDF]
Alqarawi FK +8 more
europepmc +1 more source
Decompression and Enucleation of a Mandibular Radicular Cyst, Followed by Bone Regeneration and Implant-Supported Dental Restoration. [PDF]
AboulHosn M +4 more
europepmc +1 more source
Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra +6 more
wiley +1 more source
The Impact of Repeated Steam Sterilization Cycles on the Efficacy of Chairside Adjustment Kits for Polishing Monolithic Multi-Layered Zirconia Dental Restoration Material. [PDF]
Sayed ME +14 more
europepmc +1 more source
Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang +9 more
wiley +1 more source

