Results 101 to 110 of about 71,499 (301)

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Current options concerning the endodontically-treated teeth restoration with the adhesive approach

Brazilian Oral Research, 2018
: Adhesive procedures have changed the way to restore endodontically treated teeth (ETT). It started with the shift from cast post-and-core to fiber post.
Marco Aurélio de Carvalho, Priscilla Cardoso Lazari, Marco Gresnigt, Altair Antoninha Del Bel Cury, Pascal Magne   +4 more
doaj   +1 more source

Evaluating the Trends for Restorative Treatment, Reasons and Management of Failures in General Dental Practices of Hail Region, Saudi Arabia

Dental Research and Management, 2019
Aim: The study aims to identify the common causes of performing restoration of teeth in General Dental Practice (GDP). Analyze the common reasons for restoration failure, the material used in the management of restoration repair/replacement in Hail, Saudi Arabia.
Fahad Abdulrahman Alnasrallah, Ibrahim Khalil Al Ibrahim, Muteb Sayer Alshammari, Abdullah Muteb Alanazi, Rashid Iqbal Mian, Ahad Sayer Alshammari   +5 more
openaire   +1 more source

Cortico‐Striatal‐Midbrain Circuit Dysregulation Underlying MK‐801 Induced Impulsivity and the Ameliorative Effects of SEP

Advanced Science, EarlyView.
Impulsivity is a symptom across multiple psychiatric disorders, yet its neural basis remains elusive. This study shows that the NMDAR antagonist MK‐801 elevates dopamine release and disrupts neuronal selectivity in the nucleus accumbens, leading to impulsive behavior.
Xueru Wang, Qinyu Li, Zijie Li, Xuejiao Wang, Hui Yuan, Pingting Yang, Ling Qin   +6 more
wiley   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

Survival and causes of failed amalgam restorations

Journal of Bahria University Medical and Dental College, 2014
Objective: To determine the reasons for failure of amalgam restorations and evaluate the association between the reasons for failure of restorations with gender, classes of cavities, and teeth involved.
Shama Asghar, Farheen Fatima
doaj  

The Antimicrobial Effect of Silver Ion Impregnation into Endodontic Sealer against Streptococcus mutans. [PDF]

, 2008
Pulpal and periradicular diseases are primarily caused by bacterial invasion of the root canal system as a result of caries progression. The presence of residual bacteria at the time of root canal completion (obturation) is associated with significantly ...
Chugal, N, Hsiao, G, Kang, MK, Kim, D, Kreth, J, Mito, R, Nguyen, M, Shi, W   +7 more
core   +3 more sources

NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex

Advanced Science, EarlyView.
The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang, Tinghong Liu, Zhirong Wei, Jinshan Xu, Jiayi Han, Jiaqi Wang, Feng Zhai, Yiran Tian, Shuli Liang   +8 more
wiley   +1 more source

Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond

Advanced Science, EarlyView.
Dental stem cell (DSC) aging involves genomic instability, mitochondrial dysfunction, telomere attrition, and epigenetic alterations, leading to impaired proliferation, reduced differentiation potential, and pro‐inflammatory secretory activity. These processes drive cellular senescence and compromise regenerative and immunomodulatory functions, thereby
Xinyuan Zhao, Yunfan Lin, Pei Lin, Ye Lu, Jiarong Zheng, Xu Chen, Zihao Zhou, Li Cui   +7 more
wiley   +1 more source

The effect of smoking on survival and bone loss of implants with a fluoride-modified surface: a 2-year retrospective analysis of 1106 implants placed in daily practice [PDF]

, 2012
Aim: To compare survival and peri-implant bone loss of implants with a fluoride-modified surface in smokers and nonsmokers. Materials and Methods: Patient files of all patients referred for implant treatment from November 2004 to 2007 were scrutinized.
Collaert, Bruno, Cosyn, Jan, De Bruyn, Hugo, Deschepper, Ellen, Vandeweghe, Stefan, Vervaeke, Stijn   +5 more
core   +1 more source