Results 281 to 290 of about 117,269 (356)

Aβ antibodies target not only amyloid plaques but also distinct brain cells and vessels

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract BACKGROUND Amyloid beta (Aβ) antibodies are the only therapies to slow cognitive decline in Alzheimer's disease (AD). Yet the sites where antibodies engage Aβ in the brain and mechanisms that lower Aβ are not fully understood. Defining Aβ antibody localizations in the brain is essential to understand how immunotherapy is beneficial for AD ...
Gehua Wen, Nils Lindblom, Xiaoni Zhan, Megg Garcia‐Ryde, Tomas Deierborg, Asgeir Kobro‐Flatmoen, Gunnar K. Gouras   +6 more
wiley   +1 more source

GABA_B receptors negatively modulate excitatory plasticity at the mossy fiber synapse onto parvalbumin-expressing basket and axo-axonic cells in the dentate gyrus. [PDF]

Front Synaptic Neurosci
Loureiro RM, Booker SA, Kulik A, Vida I.
europepmc   +1 more source

A Meta‐Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence With Existing Human Data

Brain and Behavior, Volume 16, Issue 1, January 2026.
Chronic stress is linked to many human psychiatric disorders involving the prefrontal cortex (PFC). We performed a meta‐analysis of public transcriptional profiling data that showed that chronically stressed mice have less gene expression for glia and neural activity in the PFC. These findings mirror patterns seen in psychiatric patients.
Jinglin Xiong, Megan H. Hagenauer, Cosette A. Rhoads, Elizabeth Flandreau, Nancy Rempel‐Clower, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Toni Duan, Stanley Watson Jr., Huda Akil   +10 more
wiley   +1 more source

Impaired spatial coding of the hippocampus in a dentate gyrus hypoplasia mouse model. [PDF]

Proc Natl Acad Sci U S A
Chen X, Cheng N, Wang C, Knierim JJ.
europepmc   +1 more source

Postnatal Development of the Perirhinal and Parahippocampal Cortices: A Stereological Study in Macaque Monkeys

Journal of Comparative Neurology, Volume 534, Issue 1, January 2026.
Volumetric data reveal a late maturation of areas 36r and 36c compared to areas 35, TF, and TH, as well as a tendency for superficial layers in areas 36r and 36c to mature earlier than the deep layers. Neuronal soma size exhibits a transient increase at 6 months of age in most subdivisions.
Justine Villard, Loïc J. Chareyron, Pamela Banta Lavenex, David G. Amaral, Pierre Lavenex   +4 more
wiley   +1 more source

γ-Aminobutyric Acid Transporter Mutation GAT1 (S295L) Substantially Impairs Neurogenesis in Dentate Gyrus. [PDF]

Brain Sci
Liu W, Yang Y, Liu Y, Ni B, Zhuang H, Chen K, Shi J, Zhu C, Wang H, Fei J.   +9 more
europepmc   +1 more source

Association Between Carotid Atherosclerosis and Post‐Stroke Cognitive Impairment in Patients With Mild Ischemic Stroke: A Prospective Cohort Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Carotid ultrasound parameters, particularly Crouse score and severe carotid stenosis, are independently associated with post‐stroke cognitive impairment and may serve as simple, non‐invasive predictors for early risk stratification. ABSTRACT Background Post‐stroke cognitive impairment (PSCI) is a common yet frequently overlooked complication that ...
GuanHua Nie, ZhiHong Wei, Zhan Su, Haining Zhang   +3 more
wiley   +1 more source

Protective exercise responses in the dentate gyrus of Alzheimer's disease mouse model revealed with single-nucleus RNA-sequencing. [PDF]

Nat Neurosci
da Rocha JF, Lance ML, Luo R, Schlachter P, Moreira L, Iqbal MA, Kuhn P, Gardner RS, Valaris S, Islam MR, Gassner GM, Mazuera S, Healy K, Shastri S, Hibbert NB, Moran-Figueroa KV, Haley EB, Pfeiffer RD, Aygar S, Kastanenka KV, Brase L, Harari O, Benitez BA, Tucker NR, Wrann CD.   +24 more
europepmc   +1 more source

Disodium Cromoglycate Attenuates the Depressive‐Like Behaviors in Mice by Inhibiting Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Mast cells were increased in the brain of depression model mice. Administration of Disodium Cromoglycate could alleviate depressive‐like behaviors in mice of LPS and CRS models. Administration of Disodium Cromoglycate mitigated the infiltration of mast cells in brain and down‐reuglated the expression of pro‐inflammatory factors in the brain of ...
Yun Xiao, Kaifan Liu, Zengqiang Yuan, Yajin Liao   +3 more
wiley   +1 more source

Dentate gyrus granule cell activation following extracellular electrical stimulation: a multi-scale computational model to guide hippocampal neurostimulation strategies. [PDF]

Front Comput Neurosci
Farzad S, Wei T, Bouteiller JC, Lazzi G.
europepmc   +1 more source