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Adult neurogenesis in the mammalian dentate gyrus
Anatomia, Histologia, Embryologia, 2019AbstractEarlier observations in neuroscience suggested that no new neurons form in the mature central nervous system. Evidence now indicates that new neurons do form in the adult mammalian brain. Two regions of the mature mammalian brain generate new neurons: (a) the border of the lateral ventricles of the brain (subventricular zone) and (b) the ...
Louise C. Abbott, Fikru Nigussie
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Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus
Nature, 2018 Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by environmental influences, and functionally implicated in behavioural responses to stress and antidepressants1–4.
Christoph Anacker +2 more
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An analysis of dentate gyrus function (an update)
Behavioural Brain Research, 2018In this review there will be a description of the dentate gyrus (DG) neural circuitry that mediates the operation of a variety of mnemonic processes associated with dorsal and ventral DG function in rats. Dysfunction of the dorsal DG can be shown to mediate mnemonic processing of spatially based information including a) the operation of conjunctive ...
R. Kesner
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Dentate Gyrus Immaturity in Schizophrenia
The Neuroscientist, 2019Hippocampal abnormalities have been heavily implicated in the pathophysiology of schizophrenia. The dentate gyrus of the hippocampus was shown to manifest an immature molecular profile in schizophrenia subjects, as well as in various animal models of the disorder.
Ayda Tavitian +4 more
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Dentate gyrus neurogenesis and depression [PDF]
, 2007 Major depressive disorder (MDD) is a debilitating and complex psychiatric disorder that involves multiple neural circuits and genetic and non-genetic risk factors. In the quest for elucidating the neurobiological basis of MDD, hippocampal neurogenesis has emerged as a candidate substrate, both for the etiology as well as treatment of MDD.
Michael R. Drew, Amar Sahay, René Hen
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2007
Computational modeling has become an increasingly useful tool for studying complex neuronal circuits such as the dentate gyrus. In order to effectively apply computational techniques and theories to answer pressing biological questions, however, it is necessary to develop detailed, data-driven models. Development of such models is a complicated process,
Vijayalakshmi Santhakumar +2 more
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Computational modeling has become an increasingly useful tool for studying complex neuronal circuits such as the dentate gyrus. In order to effectively apply computational techniques and theories to answer pressing biological questions, however, it is necessary to develop detailed, data-driven models. Development of such models is a complicated process,
Vijayalakshmi Santhakumar +2 more
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Structure, function, and plasticity of hippocampal dentate gyrus microcircuits
Frontiers in Neural Circuits, 2014 The hippocampus mediates several higher brain functions, such as learning, memory, and spatial coding. The input region of the hippocampus, the dentate gyrus, plays a critical role in these processes.
Peter Jonas
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Neuropeptide Y in the dentate gyrus
2007Neuropeptide Y (NPY) is contained in at least four types of GABAergic interneurons in the dentate gyrus, many of which also contain somatostatin and give rise to the dense NPY innervation of the dentate outer molecular layer. In humans but not rats, minute amounts of NPY are also normally expressed in dentate granule cells, while seizure activity in ...
William F. Colmers +2 more
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Opioid systems in the dentate gyrus
2007Opiate drugs alter cognitive performance and influence hippocampal excitability, including long-term potentiation (LTP) and seizure activity. The dentate gyrus (DG) contains two major opioid peptides, enkephalins and dynorphins, which have opposing effects on excitability. Enkephalins preferentially bind to delta- and mu-opioid receptors (DORs and MORs)
Carrie T. Drake +2 more
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