Results 291 to 300 of about 117,269 (356)

Elevated CHI3L1 as a Potential Biomarker of Cognitive Dysfunction in Anti‐NMDAR Encephalitis: Evidence From Clinical Results and Mice Model

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Astrocyte‐derived CHI3L1 is elevated in both a mouse model and pediatric patients with anti‐NMDAR encephalitis, coinciding with impaired hippocampal neurogenesis and cognitive deficits. CHI3L1 may serve as a potential biomarker for long‐term cognitive dysfunction in anti‐NMDAR encephalitis. ABSTRACT Background Anti‐N‐methyl‐D‐aspartate receptor (NMDAR)
Yuhang Li, Ran Ding, Jiaxin Yang, Xiaoyue Yang, Ziyao Han, Xue Li, Jie Liu, Yan Jiang, Li Cheng, Jiannan Ma, Hanyu Luo, Li Jiang   +11 more
wiley   +1 more source

Mechanisms Underlying Hyperexcitability: Combining Mossy Fiber Sprouting and Mossy Cell Loss in Neural Network Model of the Dentate Gyrus. [PDF]

Biomedicines
Świetlik D.
europepmc   +1 more source

Therapeutic Hypothermia Alleviates Hydrocephalus and Neurological Dysfunction Post Intraventricular Hemorrhage by Enhancing Drainage of Glymphatic‐Meningeal Lymphatic‐Deep Cervical Lymphatic System

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
TH is expected to be a novel therapeutic strategy for hydrocephalus and neurological dysfunction post IVH. TH alleviates hydrocephalus post IVH by enhancing drainage of the glymphatic‐meningeal lymphatic‐deep cervical lymphatic system, which is the connection between the central nervous system and peripheral lymphatic system.
Yijian Yang, Qian Ouyang, Yaxin Sun, Aijun Liang, Junqiang Wang, Kaiyue Wang, Yexin Yuan, Zhikun Liu, Jun Huang, Zhiping Zhang, Libin Wang, Yang Yuan, Cheng Wang, Zhangjie Su, Qinghua Zhang, Liyang Zhang, Gelei Xiao   +16 more
wiley   +1 more source

Dentate gyrus norepinephrine ramping facilitates aversive contextual processing. [PDF]

Nat Commun
Zhang ET, Saglimbeni GS, Feng J, Li Y, Bruchas MR.   +4 more
europepmc   +1 more source

Neuronal THY1 Signaling Maintains Astrocytes in a Quiescent State

Glia, Volume 74, Issue 1, January 2026.
THY1‐bearing neurons keep astrocytes in a quiescent state via the interaction with ITGB1. Depletion of THY1 supports the development of a partially activated astrocyte phenotype. Neuronal THY1 is involved in the maintenance and restoration of tissue homeostasis in the brain. ABSTRACT THY1 is a cell surface protein of mature neurons.
Juliane Loui, Ute Krügel, Ulrike Winkler, Anja Reinert, Dorit John, Johannes Hirrlinger, Anja Saalbach   +6 more
wiley   +1 more source

Mitotic Activity, Cell Survival, and Neuronal Differentiation in the Hilus of the Dentate Gyrus Under Physiological and Hypothyroid Conditions in Adult Wistar Rats. [PDF]

Cells
Sánchez-Huerta K, García-Juárez AK, Colmenero-Rodríguez LD, García-Martínez Y, Pacheco-Rosado J.   +4 more
europepmc   +1 more source

Astrocytic Igfbp2 Promotes Spontaneous Seizures in a Mouse Model of Mesial Temporal Lobe Epilepsy

Glia, Volume 74, Issue 1, January 2026.
Igfbp2 is upregulated in hippocampal astrocytes of MTLE model mice. Igfbp2 enhances dentate granule cell excitability. Astrocytic Igfbp2 deletion reduces spontaneous seizures. ABSTRACT Mesial temporal lobe epilepsy (MTLE) is a common, frequently drug‐resistant epilepsy characterized by seizures arising from the hippocampus.
Shinichi Kinoshita, Nobuyoshi Matsumoto, Shota Morikawa, Yuji Ikegaya, Ryuta Koyama   +4 more
wiley   +1 more source

Dentate gyrus and CA3 activity mediates light-tone second-order conditioning expression in mice

Canela M, Adell JB, Coll DR, González-Parra JA, Pinho JS, Busquets-García A.   +5 more
europepmc   +1 more source

Increased excitability of dentate gyrus mossy cells occurs early in life in the Tg2576 model of Alzheimer's disease. [PDF]

Alzheimers Res Ther
Alcantara-Gonzalez D, Kennedy M, Criscuolo C, Botterill J, Scharfman HE.   +4 more
europepmc   +1 more source

Entorhinal Silencing Reveals Energy Cascade Organization of Hippocampal Oscillations

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT Hippocampal theta and gamma rhythms are often viewed as discrete channels supporting distinct cognitive operations. In particular, “gamma multiplexing” models propose that slow and fast gamma bands independently encode separate information streams or memory processes.
Ben Zhao, Yu Qin, Sara N. Burke, Andrew P. Maurer   +3 more
wiley   +1 more source