Results 301 to 310 of about 116,345 (333)
Some of the next articles are maybe not open access.
Somatostatin in the dentate gyrus
2007The neuropeptide somatostatin (SST) is expressed in a discrete population of interneurons in the dentate gyrus. These interneurons have their soma in the hilus and project to the outer molecular layer onto dendrites of dentate granule cells, adjacent to perforant path input.
openaire +2 more sources
On the number of neurons in the dentate gyrus of the rat
Brain Research, 1985We have estimated the number of dentate granule cells in Sprague-Dawley and Wistar rats at 1, 4 and 12 months of age. In Sprague-Dawley rats the number of granule cells is relatively constant throughout this period at about 1 million. In Wistar rats, on the other hand, there is a progressive increase in the number from about 700,000 at 1 month to 1 ...
B D, Boss, G M, Peterson, W M, Cowan
openaire +2 more sources
Dentate gyrus neurogenesis and depression
2007Major depressive disorder (MDD) is a debilitating and complex psychiatric disorder that involves multiple neural circuits and genetic and non-genetic risk factors. In the quest for elucidating the neurobiological basis of MDD, hippocampal neurogenesis has emerged as a candidate substrate, both for the etiology as well as treatment of MDD.
Amar, Sahay, Michael R, Drew, Rene, Hen
openaire +2 more sources
An analysis of the dentate gyrus function
Behavioural Brain Research, 2013In this review article the emphasis will be on the role of the DG (dorsal and ventral) in supporting memory based on the operation of specific processes. Based on the development of computational models of dorsal dentate gyrus (dDG) and behavioral evidence based on dysfunction of dDG, this review will show that the dDG mediates mnemonic processing of ...
openaire +2 more sources
Electrophysiology of dentate gyrus granule cells
Journal of Neurophysiology, 1984The orthodromic synaptic responses, membrane properties, and responses of dentate gyrus granule cells (DGCs) to several convulsant agents were studied in the in vitro hippocampal slice preparation. Orthodromic stimulation via the perforant pathway (PP) evoked excitatory-inhibitory postsynaptic potentials (EPSP-IPSP) sequences in 27 of 34 DGCs studied.
R A, Fricke, D A, Prince
openaire +2 more sources
Adult neurogenesis in the mammalian dentate gyrus
Anatomia, Histologia, Embryologia, 2019AbstractEarlier observations in neuroscience suggested that no new neurons form in the mature central nervous system. Evidence now indicates that new neurons do form in the adult mammalian brain. Two regions of the mature mammalian brain generate new neurons: (a) the border of the lateral ventricles of the brain (subventricular zone) and (b) the ...
Louise C. Abbott, Fikru Nigussie
openaire +2 more sources
An analysis of dentate gyrus function (an update)
Behavioural Brain Research, 2018In this review there will be a description of the dentate gyrus (DG) neural circuitry that mediates the operation of a variety of mnemonic processes associated with dorsal and ventral DG function in rats. Dysfunction of the dorsal DG can be shown to mediate mnemonic processing of spatially based information including a) the operation of conjunctive ...
openaire +2 more sources
Ethanol neurotoxicity and dentate gyrus development
Congenital Anomalies, 2008ABSTRACT  Maternal alcohol ingestion during pregnancy adversely affects the developing fetus, often leading to fetal alcohol syndrome (FAS). One of the most severe consequences of FAS is brain damage that is manifested as cognitive, learning, and behavioral deficits. The hippocampus plays a crucial role in such abilities; it is also known as one of the
Miki, Takanori +10 more
openaire +3 more sources
The dentate gyrus in Alzheimer's disease
2007As part of the hippocampus, the dentate gyrus is considered to play a crucial role in associative memory. The reviewed data suggest that the dentate gyrus withstands the formation of plaques, tangles and neuronal death until late stages of Alzheimer's disease (AD).
openaire +2 more sources
Genetic regulation of dentate gyrus morphogenesis
2007The dentate gyrus is one of the small number of forebrain areas that have continued adult neurogenesis. During development the dentate gyrus acquires the capacity for neurogenesis by generating a new neurogenic stem cell niche at the border between the hilus and dentate granule cell layer. This is in distinction to the other prominent zone of continued
Guangnan, Li, Samuel J, Pleasure
openaire +2 more sources