Results 71 to 80 of about 8,702 (246)

Constitutive expression of spliced X-box binding protein 1 inhibits dentin formation in mice

open access: yesFrontiers in Physiology
Upon endoplasmic reticulum (ER) stress, inositol-requiring enzyme 1 (IRE1) is activated, which subsequently converts an unspliced X-box binding protein 1 (XBP1U) mRNA to a spliced mRNA that encodes a potent XBP1S transcription factor.
Qian Xu   +5 more
doaj   +1 more source

Clinical and Molecular Heterogeneity Underlying Monogenic Causes of Pediatric Diabetes Associated to Brain Developmental Disorders

open access: yesClinical Genetics, Volume 108, Issue 5, Page 495-510, November 2025.
A growing number of genetic variants linking non‐autoimmune diabetes to NDDs across different ages offer key insights about a common background of these phenotypes. These findings call for multidisciplinary approaches to care that integrate metabolic and neurological management in affected children.
Gabriele Di Pasquale   +6 more
wiley   +1 more source

Serum creatine kinase isoenzymes in children with osteogenesis imperfecta [PDF]

open access: yes, 2017
This study evaluates serum creatine kinase isoenzyme activity in children with osteogenesis imperfecta to determine its usefulness as a biochemical marker during treatment with bisphosphonate.
Celli, L   +8 more
core   +1 more source

Gene-Expression Analysis Identifies IGFBP2 Dysregulation in Dental Pulp Cells From Human Cleidocranial Dysplasia

open access: yesFrontiers in Genetics, 2018
Cleidocranial dysplasia (CCD) is an autosomal dominant disorder affecting osteoblast differentiation, chondrocyte maturation, skeletal morphogenesis, and tooth formation.
Stephen L. Greene   +5 more
doaj   +1 more source

Lobodontia‐Affected Teeth Exhibit Compromised Integrity and Enamel Defects: A Deep Phenotyping Study

open access: yesOral Diseases, Volume 31, Issue 11, Page 3115-3125, November 2025.
ABSTRACT Objective Lobodontia, a complex tooth disorder characterized by carnivore‐like dentition, presents unique clinical challenges. This study aimed to characterize the physical, mechanical, and ultrastructural properties of lobodontia teeth to inform precision treatment strategies.
Thanakorn Theerapanon   +7 more
wiley   +1 more source

Current applications and future prospects of stem cells in dentistry [PDF]

open access: yes, 2015
Stem cells are defined as clonogenic, unspecialized cells capable of both self-renewal and multi-lineage differentiation, contributing to regenerating specific tissues. For years, restorative treatments have exploited the lifelong regenerative potential
Sivamurthy, Gautham, Surendran, Sharmila
core   +2 more sources

Histone Acetylation as a Regenerative Target in the Dentine-Pulp Complex

open access: yesFrontiers in Genetics, 2020
If dental caries (or tooth decay) progresses without intervention, the infection will advance through the dentine leading to severe pulpal inflammation (irreversible pulpitis) and pulp death.
Yukako Yamauchi   +5 more
doaj   +1 more source

Treatment Outcomes of Revascularization and Cervical Pulpotomy in Immature Traumatized Maxillary Incisors: A Case Report With 24 Months Follow‐Up

open access: yesClinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT This report compares regenerative endodontic procedures (REPs) and vital pulp therapies (VPTs) in traumatized immature maxillary incisors of a 7‐year‐old patient. Following a bicycle accident, teeth #9 and #8 presented with crown fractures, subluxation, and negative pulp tests.
Motahareh Khosrojerdi   +2 more
wiley   +1 more source

Penicillin Disrupts Dental Mineralization in Rats: A Comparative Study With Tetracycline Highlighting Prenatal and Postnatal Risks

open access: yesClinical and Experimental Dental Research, Volume 11, Issue 5, October 2025.
ABSTRACT Objectives Penicillin's impact on enamel defects remains understudied, particularly regarding its ability to cause structural issues even at therapeutic doses. Material and Methods Pregnant Wistar rats received daily gavage from gestational day 13–22 with saline (control), 130 mg/kg tetracycline, 50 mg/kg penicillin, or 100 mg/kg penicillin ...
Sedigheh Mozafar   +7 more
wiley   +1 more source

An unusual presentation of osteogenesis imperfecta type I [PDF]

open access: yes, 2011
Marta Rebelo, Jandira Lima, José Diniz Vieira, José Nascimento CostaDepartment of Internal Medicine, University Hospital of Coimbra, Coimbra, PortugalAbstract: Osteogenesis imperfecta (OI) is a rare inherited disorder with a broad ...
Costa JN, Lima J, Rebelo M, Vieira JD
core   +1 more source

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