Results 1 to 10 of about 7,290 (223)

Hydrostatic pressure promotes odontoblast differentiation via PIEZO1-dependent activation of RUNX2 and WNT16 in SHED [PDF]

Scientific Reports
Mechanical stimulation plays a crucial role in odontoblast differentiation. However, the underlying molecular mechanisms remain unclear. We have previously shown that hydrostatic pressure (HP) applied to stem cells from human exfoliated deciduous teeth ...
Aya Miyazaki, Anrizandy Narwidina, Asuna Sugimoto, Rika Kurogoushi, Yumiko Nakashima, Noboru Hashimoto, Akihito Yamamoto, Tsutomu Iwamoto   +7 more
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MARCH2 suppresses odontoblast differentiation by polyubiquitinating PTPRD [PDF]

International Journal of Oral Science
Dentin, the main component of dental hard tissues, is produced by differentiated odontoblasts. How odontoblast differentiation is regulated remains understudied. Here, we screen that the expression of membrane-associated RING finger protein 2 (March2) is
Hao Feng, Jiaxin Niu, Zhi Chen, Guobin Yang, Guohua Yuan   +4 more
doaj   +2 more sources

Piezo channels contribute to the terminal cytodifferentiation of odontoblasts via modulation of canonical Wnt signaling [PDF]

International Journal of Oral Science
Piezo1 and Piezo2 are mechanosensitive ion channels that transduce mechanical stimuli into intracellular biochemical signals in diverse tissues and organ systems. Their functions in odontoblast development are still not well understood. In this study, we
Xuguang Nie, Kelley Huang, Emily Chu, Man-Kyo Chung   +3 more
doaj   +2 more sources

Histological investigation of the effects of chitosan and 3 different pulpotomy agents on rat dental pulps [PDF]

BMC Oral Health
Background Pulpotomy is a vital pulp therapy performed following the removal of infected or affected coronal pulp. However, there is no consensus on the most effective pulpotomy agent.
Kübra Pedük, Salih Doğan, Nurhan Özalp, Kenan Cantekin, Esra Balcıoğlu, Özge Göktepe   +5 more
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The Enhancing Effects of Amelogenin Exon 5-Encoded Peptide from Enamel Matrix Derivative on Odontoblast-Like KN-3 Cells

Applied Sciences, 2018
Enamel matrix derivative (EMD) is applied for periodontal therapy. We created a synthetic amelogenin peptide (SP) derived from EMD, and have previously investigated the biological function of SP.
Hirohito Kato, Yoichiro Taguchi, Kazutaka Imai, Yaru Ruan, Yu-Wei Tsai, Yi-Chie Chen, Muneyasu Shida, Reiko Taguchi, Kazuya Tominaga, Makoto Umeda   +9 more
doaj   +3 more sources

Chromatin Accessibility Predetermines Odontoblast Terminal Differentiation

Frontiers in Cell and Developmental Biology, 2021
Embryonic development and stem cell differentiation are orchestrated by changes in sequential binding of regulatory transcriptional factors to their motifs.
Qian Zhang, Zhen Huang, Huanyan Zuo, Yuxiu Lin, Yao Xiao, Yanan Yan, Yu Cui, Chujiao Lin, Fei Pei, Zhi Chen, Huan Liu, Huan Liu   +11 more
doaj   +1 more source

Atp6i deficient mouse model uncovers transforming growth factor-β1 /Smad2/3 as a key signaling pathway regulating odontoblast differentiation and tooth root formation

International Journal of Oral Science, 2023
The biomolecular mechanisms that regulate tooth root development and odontoblast differentiation are poorly understood. We found that Atp6i deficient mice (Atp6i −/− ) arrested tooth root formation, indicated by truncated Hertwig’s epithelial root sheath
Jue Wang, Abigail McVicar, Yilin Chen, Hong-Wen Deng, Zhihe Zhao, Wei Chen, Yi-Ping Li   +6 more
doaj   +1 more source

Role of connexin 43 in odontoblastic differentiation and structural maintenance in pulp damage repair

International Journal of Oral Science, 2021
Dental pulp can initiate its damage repair after an injury of the pulp–dentin complex by rearrangement of odontoblasts and formation of newly differentiated odontoblast-like cells.
Jiaxin Yin, Jue Xu, Ran Cheng, Meiying Shao, Yuandong Qin, Hui Yang, Tao Hu   +6 more
doaj   +1 more source

Effect of angiopoietin 4 on odontogenic differentiation of dental pulp stem cells

口腔疾病防治, 2023
Objective To investigate the effects of angiopoietin 4 (ANGPT4) on the odontogenic differentiation of human dental pulp stem cells. Methods This study has been reviewed and approved by the Ethics Committee, and informed consent has been obtained from ...
FAN Xinyi, LIU Cangwei , ZHOU Yijun , REN Feilong, SHI Ce, SUN Hongchen   +5 more
doaj   +1 more source

Laminin-Modified Dental Pulp Extracellular Matrix for Dental Pulp Regeneration

Frontiers in Bioengineering and Biotechnology, 2021
Native dental pulp extracellular matrix (DPEM) has proven to be an effective biomaterial for dental pulp regeneration. However, as a significant extracellular matrix glycoprotein, partial laminins were lost during the decellularization process, which ...
Jiahui Fu, Jianfeng Chen, Wenjun Li, Xiaomin Yang, Jingyan Yang, Huixin Quan, Haitao Huang, Gang Chen, Gang Chen   +8 more
doaj   +1 more source