HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation [PDF]
Frontiers in Cell and Developmental Biology, 2020 Odontoblast differentiation is an important process during tooth development in which pre-odontoblasts undergo elongation, polarization, and finally become mature secretory odontoblasts.
Yunyan Zhan +4 more
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Atp6i deficient mouse model uncovers transforming growth factor-β1 /Smad2/3 as a key signaling pathway regulating odontoblast differentiation and tooth root formation [PDF]
International Journal of Oral Science, 2023 The biomolecular mechanisms that regulate tooth root development and odontoblast differentiation are poorly understood. We found that Atp6i deficient mice (Atp6i −/− ) arrested tooth root formation, indicated by truncated Hertwig’s epithelial root sheath
Jue Wang +6 more
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Hypoxia-inducible factor 1α induces osteo/odontoblast differentiation of human dental pulp stem cells via Wnt/β-catenin transcriptional cofactor BCL9 [PDF]
Scientific Reports, 2022 Accelerated dental pulp mineralization is a common complication in avulsed/luxated teeth, although the mechanisms underlying this remain unclear. We hypothesized that hypoxia due to vascular severance may induce osteo/odontoblast differentiation of ...
Shion Orikasa +8 more
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MARCH2 suppresses odontoblast differentiation by polyubiquitinating PTPRD [PDF]
International Journal of Oral ScienceDentin, the main component of dental hard tissues, is produced by differentiated odontoblasts. How odontoblast differentiation is regulated remains understudied. Here, we screen that the expression of membrane-associated RING finger protein 2 (March2) is
Hao Feng +4 more
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Hydrostatic pressure promotes odontoblast differentiation via PIEZO1-dependent activation of RUNX2 and WNT16 in SHED [PDF]
Scientific ReportsMechanical stimulation plays a crucial role in odontoblast differentiation. However, the underlying molecular mechanisms remain unclear. We have previously shown that hydrostatic pressure (HP) applied to stem cells from human exfoliated deciduous teeth ...
Aya Miyazaki +7 more
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Effects of Eucommia ulmoides Oliver Extracts on Odontoblast Differentiation in Human Dental Pulp Stem Cells [PDF]
Current Issues in Molecular BiologyEucommia ulmoides Oliver (E. ulmoides), a traditional medicinal plant, has been widely used for its antioxidant and anti-inflammatory properties. However, its effects on dental tissue regeneration remain largely unexplored. In this study, we investigated
Hye-Ock Jang +4 more
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Selective HDAC4 inhibition by SP1-PTD promotes odontoblast differentiation [PDF]
Journal of Applied Oral ScienceBackground Vital pulp therapy is limited by incomplete dentin regeneration and dose-limiting toxicities of current histone deacetylase (HDAC) inhibitors.
Yeo-Kyeong SHIN +7 more
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Piezo channels contribute to the terminal cytodifferentiation of odontoblasts via modulation of canonical Wnt signaling [PDF]
International Journal of Oral SciencePiezo1 and Piezo2 are mechanosensitive ion channels that transduce mechanical stimuli into intracellular biochemical signals in diverse tissues and organ systems. Their functions in odontoblast development are still not well understood. In this study, we
Xuguang Nie +3 more
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The Biofunctional Monomer, the Calcium Salt of 4-Methacryloxyethyl Trimellitic Acid, Promotes Odontoblast Differentiation in Three-Dimensional Culture System [PDF]
International Journal of BiomaterialsThis study evaluated the effects of the biofunctional monomer CMET on the proliferation, differentiation, and mineralization of MDPC-23, odontoblast-like cells in a three-dimensional (3D) culture system using type I collagen. CMET (0.3%, w/v) facilitated
Yaxin Rao, Youjing Qiu, Takashi Saito
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Dentin Phosphophoryn-Derived Peptide Promotes Odontoblast Differentiation in Vitro and Dentin Regeneration in Vivo [PDF]
Materials, 2021 Takashi Saito +2 more
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