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Odontoblasts in Equine Hypsodont Teeth—How They Cope with Permanent Occlusal Wear [PDF]

Animals
Horses’ hypsodont (high-crowned) teeth face permanent dental wear. This is compensated for by a continuous eruption, which requires a high adaptability of odontoblasts; otherwise, the dental pulp would be exposed.
Laura Beate Heilen, Jessica Roßgardt, Jutta Dern-Wieloch, Jörg Vogelsberg, Carsten Staszyk   +4 more
doaj   +2 more sources

Plasma Membrane Ca²⁺–ATPase in Rat and Human Odontoblasts Mediates Dentin Mineralization [PDF]

Biomolecules, 2021
Intracellular Ca2+ signaling engendered by Ca2+ influx and mobilization in odontoblasts is critical for dentinogenesis induced by multiple stimuli at the dentin surface.
Maki Kimura, Hiroyuki Mochizuki, Ryouichi Satou, Miyu Iwasaki, Eitoyo Kokubu, Kyosuke Kono, Sachie Nomura, Takeshi Sakurai, Hidetaka Kuroda, Yoshiyuki Shibukawa   +9 more
doaj   +2 more sources

Exosomes derived from human dental stem cell enhance the viability of odontoblasts [PDF]

Nanomedicine Research Journal, 2023
Objective(s): The purpose of this study was to assess the effects of exosomes derived from dental pulp mesenchymal stem cells (DPSCs) on the viability of odontoblast cells.Methods: Exosomes were extracted from human DPSC cells via ultracentrifugation ...
Kamyar Nasiri
doaj   +1 more source

CPNE7-Induced Autophagy Restores the Physiological Function of Mature Odontoblasts

Frontiers in Cell and Developmental Biology, 2021
Dentin, which composes most of the tooth structure, is formed by odontoblasts, long-lived post-mitotic cells maintained throughout the entire life of the tooth. In mature odontoblasts, however, cellular activity is significantly weakened.
Yeoung-Hyun Park, Yeoung-Hyun Park, Chul Son, You-Mi Seo, Yoon Seon Lee, Alix Har, Joo-Cheol Park, Joo-Cheol Park   +7 more
doaj   +1 more source

Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis

Frontiers in Physiology, 2022
Dentinogenesis is a key process in tooth formation and is regulated by a series of pre- and post-transcriptional regulations. N6-methyl-adenosine (m6A), which is the most prevalent internal chemical modification that can be removed by the RNA demethylase
Cheng Tian, Jihua Chai, Weidong Liu, Xinye Zhang, Yashu Li, Huanyan Zuo, Guohua Yuan, Haojian Zhang, Haojian Zhang, Huan Liu, Huan Liu, Zhi Chen, Zhi Chen   +12 more
doaj   +1 more source

Deficiency of Mineralization-Regulating Transcription Factor Trps1 Compromises Quality of Dental Tissues and Increases Susceptibility to Dental Caries

Frontiers in Dental Medicine, 2022
Dental caries is the most common chronic disease in children and adults worldwide. The complex etiology of dental caries includes environmental factors as well as host genetics, which together contribute to inter-individual variation in susceptibility ...
Mairobys Socorro, Priyanka Hoskere, Catherine Roberts, Lyudmila Lukashova, Kostas Verdelis, Kostas Verdelis, Kostas Verdelis, Elia Beniash, Elia Beniash, Dobrawa Napierala, Dobrawa Napierala   +10 more
doaj   +1 more source

circKLF4 Upregulates Klf4 and Endoglin to Promote Odontoblastic Differentiation of Mouse Dental Papilla Cells via Sponging miRNA-1895 and miRNA-5046

Frontiers in Physiology, 2022
circular RNAs (circRNAs) is a broad and diverse endogenous subfamily of non-coding RNAs, regulating the gene expression by acting as a microRNA (miRNA) sponge.
Yue Zhang, Hao Zhang, Guohua Yuan, Guobin Yang   +3 more
doaj   +1 more source

Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization

Frontiers in Physiology, 2021
Odontoblasts play critical roles in dentin formation and sensory transduction following stimuli on the dentin surface. Exogenous stimuli to the dentin surface elicit dentinal sensitivity through the movement of fluids in dentinal tubules, resulting in ...
Mayumi Matsunaga, Mayumi Matsunaga, Maki Kimura, Takehito Ouchi, Takashi Nakamura, Sadao Ohyama, Masayuki Ando, Sachie Nomura, Toshifumi Azuma, Tatsuya Ichinohe, Yoshiyuki Shibukawa   +10 more
doaj   +1 more source

Pathological dentinogenesis in posteruptiv toot development [PDF]

Stomatološki glasnik Srbije, 2004
The most significant investigations concerning pathological dentinogenesis are reviewed in this article. Previous results point out that odontoblasts behave, either in physiological or pathological circumstances, in the genetically determined sequence of
Vojinović Jovan, Stevanović Radoje
doaj   +1 more source

Gα_s-Coupled CGRP Receptor Signaling Axis from the Trigeminal Ganglion Neuron to Odontoblast Negatively Regulates Dentin Mineralization

Biomolecules, 2022
An inflammatory response following dental pulp injury and/or infection often leads to neurogenic inflammation via the axon reflex. However, the detailed mechanism underlying the occurrence of the axon reflex in the dental pulp remains unclear.
Natsuki Saito, Maki Kimura, Takehito Ouchi, Tatsuya Ichinohe, Yoshiyuki Shibukawa   +4 more
doaj   +1 more source