Results 11 to 20 of about 14,750 (276)
Functional expression of TRPM8 and TRPA1 channels in rat odontoblasts. [PDF]
PLoS ONE, 2013 Odontoblasts produce dentin during development, throughout life, and in response to pathological conditions by sensing stimulation of exposed dentin. The functional properties and localization patterns of transient receptor potential (TRP) melastatin ...
Maki Tsumura +9 more
doaj +3 more sources
Frontiers in Physiology, 2018 Odontoblasts play a crucial role in dentin formation and sensory transduction following the application of stimuli to the dentin surface. Various exogenous and endogenous stimuli elicit an increase in the intracellular free calcium concentration ([Ca2+]i)
Maki Kimura +7 more
doaj +3 more sources
Piezo1-pannexin-1-P2X3 axis in odontoblasts and neurons mediates sensory transduction in dentinal sensitivity [PDF]
Frontiers in Physiology, 2022 According to the “hydrodynamic theory,” dentinal pain or sensitivity is caused by dentinal fluid movement following the application of various stimuli to the dentin surface.
Sadao Ohyama +17 more
doaj +3 more sources
Potassium Currents Activated by Depolarization in Odontoblasts
Frontiers in Physiology, 2017 Increased intracellular free Ca2+ concentrations elicit plasma membrane depolarization, which leads to the activation of K+ currents. However, the precise properties of K+ currents activated by depolarization in odontoblasts remain to be elucidated.
Yuki Kojima +6 more
doaj +2 more sources
TRPM7 Mediates Mechanosensitivity in Adult Rat Odontoblasts
Journal of dentistry research, 2018 Odontoblasts, with their strategic arrangement along the outermost compartment of the dentin-pulp complex, have been suggested to have sensory function.
J. Won +6 more
semanticscholar +2 more sources
The roles of odontoblasts in dental pulp innate immunity
Japanese Dental Science Review, 2018 Summary Odontoblasts located in the outermost layer of dental pulp form a natural barrier between mineralized tissues, dentin, and soft tissues, dental pulp, of the vital tooth, and they first recognize caries-related pathogens and sense external ...
H. Yumoto +6 more
semanticscholar +2 more sources
Wnt-Responsive Odontoblasts Secrete New Dentin after Superficial Tooth Injury
Journal of dentistry research, 2018 The objective of our experiments was to identify new therapeutic strategies to stimulate dentin formation in an adult tooth. To address this objective, we evaluated dentin production in 2 acute trauma models: one involving a pulp exposure and the other ...
Y. Zhao +5 more
semanticscholar +2 more sources
The dynamics of TGF-β in dental pulp, odontoblasts and dentin
Scientific Reports, 2018 Transforming growth factor-beta (TGF-β) is critical for cell proliferation and differentiation in dental pulp. Here, we show the dynamic mechanisms of TGF-β in porcine dental pulp, odontoblasts and dentin.
Takahiko Niwa +10 more
semanticscholar +2 more sources
BMP-2 induced Dspp transcription is mediated by Dlx3/Osx signaling pathway in odontoblasts
Scientific Reports, 2017 Dentin sialophosphoprotein (Dspp) as a differentiation marker of odontoblasts is regulated by BMP-2. However, the intimate mechanism is still unknown. Transcription factors Dlx3 and Osx are essential for odontoblasts differentiation. We hypothesized that
Guobin Yang +4 more
semanticscholar +2 more sources
SHED Differentiate into Functional Odontoblasts and Endothelium
Journal of dentistry research, 2010 Studies on mechanisms underlying the differentiation of dental pulp stem cells are critical for the understanding of the biology of odontogenesis and for dental tissue engineering.
V. T. Sakai +7 more
semanticscholar +2 more sources