Results 11 to 20 of about 9,324 (181)

Odontoblasts in Equine Hypsodont Teeth—How They Cope with Permanent Occlusal Wear [PDF]

Animals
Horses’ hypsodont (high-crowned) teeth face permanent dental wear. This is compensated for by a continuous eruption, which requires a high adaptability of odontoblasts; otherwise, the dental pulp would be exposed.
Laura Beate Heilen, Jessica Roßgardt, Jutta Dern-Wieloch, Jörg Vogelsberg, Carsten Staszyk   +4 more
doaj   +2 more sources

Functional expression of TRPM8 and TRPA1 channels in rat odontoblasts. [PDF]

PLoS ONE, 2013
Odontoblasts produce dentin during development, throughout life, and in response to pathological conditions by sensing stimulation of exposed dentin. The functional properties and localization patterns of transient receptor potential (TRP) melastatin ...
Maki Tsumura, Ubaidus Sobhan, Masaki Sato, Miyuki Shimada, Akihiro Nishiyama, Aya Kawaguchi, Manabu Soya, Hidetaka Kuroda, Masakazu Tazaki, Yoshiyuki Shibukawa   +9 more
doaj   +2 more sources

High pH-Sensitive Store-Operated Ca2+ Entry Mediated by Ca2+ Release-Activated Ca2+ Channels in Rat Odontoblasts

Frontiers in Physiology, 2018
Odontoblasts play a crucial role in dentin formation and sensory transduction following the application of stimuli to the dentin surface. Various exogenous and endogenous stimuli elicit an increase in the intracellular free calcium concentration ([Ca2+]i)
Maki Kimura, Koichi Nishi, Asuka Higashikawa, Sadao Ohyama, Sadao Ohyama, Kaoru Sakurai, Masakazu Tazaki, Yoshiyuki Shibukawa   +7 more
doaj   +2 more sources

Potential role of odontoblasts in the innate immune response of the dental pulp [PDF]

Dental Journal, 2008
Background: Odontoblasts are the cells lining of tooth’s hard structure at the dentin-pulp border, which become the first cells encountered oral microorganisms entering dentin.
Tetiana Haniastuti
doaj   +3 more sources

Exosomes derived from human dental stem cell enhance the viability of odontoblasts [PDF]

Nanomedicine Research Journal, 2023
Objective(s): The purpose of this study was to assess the effects of exosomes derived from dental pulp mesenchymal stem cells (DPSCs) on the viability of odontoblast cells.Methods: Exosomes were extracted from human DPSC cells via ultracentrifugation ...
Kamyar Nasiri
doaj   +1 more source

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2-KLF4. [PDF]

Cell Prolif
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Zeng W, Lin Y, Gao Y, Huang D, Li Y, Ruan H, Yuan G, Liu H, Chen Z.   +8 more
europepmc   +2 more sources

CPNE7-Induced Autophagy Restores the Physiological Function of Mature Odontoblasts

Frontiers in Cell and Developmental Biology, 2021
Dentin, which composes most of the tooth structure, is formed by odontoblasts, long-lived post-mitotic cells maintained throughout the entire life of the tooth. In mature odontoblasts, however, cellular activity is significantly weakened.
Yeoung-Hyun Park, Yeoung-Hyun Park, Chul Son, You-Mi Seo, Yoon Seon Lee, Alix Har, Joo-Cheol Park, Joo-Cheol Park   +7 more
doaj   +1 more source

Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis

Frontiers in Physiology, 2022
Dentinogenesis is a key process in tooth formation and is regulated by a series of pre- and post-transcriptional regulations. N6-methyl-adenosine (m6A), which is the most prevalent internal chemical modification that can be removed by the RNA demethylase
Cheng Tian, Jihua Chai, Weidong Liu, Xinye Zhang, Yashu Li, Huanyan Zuo, Guohua Yuan, Haojian Zhang, Haojian Zhang, Huan Liu, Huan Liu, Zhi Chen, Zhi Chen   +12 more
doaj   +1 more source

Plasma Membrane Ca²⁺–ATPase in Rat and Human Odontoblasts Mediates Dentin Mineralization

Biomolecules, 2021
Intracellular Ca2+ signaling engendered by Ca2+ influx and mobilization in odontoblasts is critical for dentinogenesis induced by multiple stimuli at the dentin surface.
Maki Kimura, Hiroyuki Mochizuki, Ryouichi Satou, Miyu Iwasaki, Eitoyo Kokubu, Kyosuke Kono, Sachie Nomura, Takeshi Sakurai, Hidetaka Kuroda, Yoshiyuki Shibukawa   +9 more
doaj   +1 more source

Deficiency of Mineralization-Regulating Transcription Factor Trps1 Compromises Quality of Dental Tissues and Increases Susceptibility to Dental Caries

Frontiers in Dental Medicine, 2022
Dental caries is the most common chronic disease in children and adults worldwide. The complex etiology of dental caries includes environmental factors as well as host genetics, which together contribute to inter-individual variation in susceptibility ...
Mairobys Socorro, Priyanka Hoskere, Catherine Roberts, Lyudmila Lukashova, Kostas Verdelis, Kostas Verdelis, Kostas Verdelis, Elia Beniash, Elia Beniash, Dobrawa Napierala, Dobrawa Napierala   +10 more
doaj   +1 more source