Results 61 to 70 of about 27,818 (210)

Clinical manifestations of primary and secondary dengue in Paraguay and its relation to virus serotype

Journal of Infection in Developing Countries, 2019
Introduction: Dengue virus (DENV) infection is currently a major cause of morbidity in the world, and its incidence has mainly increased during the last years in Latin America, including Paraguay.
Dolores Lovera, Celia Martínez-Cuellar, Fernando Galeano, Sara Amarilla, Cynthia Vazquez, Antonio Arbo   +5 more
doaj   +1 more source

DENV-3 precursor membrane (prM) glycoprotein enhances E protein immunogenicity and confers protection against DENV-2 infections in a murine model

Human Vaccines & Immunotherapeutics, 2021
To improve a DNA vaccine containing the truncated dengue virus serotype 2 (DENV-2) envelope (E) protein and evaluate the influence of precursor membrane (prM) glycoprotein polymorphism on E protein immunogenicity, two vaccine candidates have been ...
Roberto S. Dias, Michelle D. Teixeira, Mariana F. Xisto, John W. O. Prates, Jessica D. Da Silva, Iago O. Mello, Cynthia C. Da Silva, Sérgio O. De Paula   +7 more
doaj   +1 more source

Defining new therapeutics using a more immunocompetent mouse model of antibody-enhanced dengue virus infection [PDF]

, 2015
With over 3.5 billion people at risk and approximately 390 million human infections per year, dengue virus (DENV) disease strains health care resources worldwide.
Barrett, Alan D, Brien, James D, Chiang, Cindy, Diamond, Michael S, Hiscott, John, Johnson, Syd, Lam, Chia-Ying Kao, Pinto, Amelia K, Sarathy, Vanessa V, Shresta, Sujan   +9 more
core   +2 more sources

Recombinant DENV 2 NS5: An effective antigen for diagnosis of DENV infection

Journal of Virological Methods, 2019
Dengue fever is a mosquito-borne viral disease with dramatically increasing morbidity rate worldwide in decades. Since there is no specific treatment to date, early diagnosis is important for providing proper timely medical care to minimize mortality, and for the prompt initiation of public health control measures.
Ting Zhang, Ming-Lian Wang, Gui-Rong Zhang, Wei Liu, Xiang-Qian Xiao, Yi-Shu Yang, Jin-Tao Li, Zhi-Ming Xun, Dan-Yang Li, Paul K.S. Chan   +9 more
openaire   +2 more sources

Circulating serotypes and genotypes of dengue virus in North India: An observational study

Journal of Vector Borne Diseases
Background & objectives: This study reports observation on circulating serotypes and genotypes of Dengue Virus in North India. Methods: Serum samples were obtained from suspected cases of dengue referred to the virus diagnostic laboratory during 2014 to ...
Om Prakash, Anil Kumar Verma, Asutosh Paliwal, Faisal Abbas, Ashish Kumar Srivastava, Vivek Kumar Mishra, Shruti Radera, Amita Jain   +7 more
doaj   +1 more source

Diversity of Dengue Virus Serotype in Endemic Region of South Sulawesi Province

Journal of Tropical Medicine, 2018
The objective of this research was to investigate serotype diversity pattern of dengue hemorrhagic fever virus by using real-time-polymerase chain reaction (RT-PCR) method.
Muh. Taslim, A. A. Arsunan, Hasanuddin Ishak, Sudirman Nasir, Andi Nilawati Usman   +4 more
doaj   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

The effect of hydrocotyle sibthorpioides lam. extract on dengue virus 2 inhibition in vitro [PDF]

, 2015
For thousands of years the practice of traditional medicine, using plant and herbs, has been effective in the treatment of various infections. Despite decades of efforts, there is no proven effective antiviral for DENV infection and attempts at vaccine
Husin, Fitrien
core  

Correction to: Multiple arboviral infections during a DENV-2 outbreak in Solomon Islands [PDF]

Tropical Medicine and Health, 2020
An amendment to this paper has been published and can be accessed via the original article.
Andrew Waleluma Darcy, Seiji Kanda, Tenneth Dalipanda, Cynthia Joshua, Takaki Shimono, Pheophet Lamaningao, Nobuyuki Mishima, Toshimasa Nishiyama   +7 more
openaire   +2 more sources

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source