ENO1-mediated deoxycytidine synthesis and gemcitabine resistance by stabilizing RRM2 in pancreatic cancer. [PDF]
Cell Death DisLi Y +8 more
europepmc +1 more source
Mitochondrial membrane remodeling in stress adaptation: Lipid control of organelle quality
Protein Science, Volume 35, Issue 8, August 2026.Abstract Mitochondria respond to proteotoxic stress through the mitochondrial unfolded protein response, traditionally viewed as a transcriptional program that restores proteostasis by inducing chaperones and proteases. Emerging evidence indicates that mitochondrial membrane remodeling constitutes an additional adaptive component of this response ...
Lena J. Reichert +2 more
wiley +1 more source
DCTPP1 orchestrates dCTP pool dynamics and mtDNA stability in quiescent cells. [PDF]
Cell Death DisFernández B +5 more
europepmc +1 more source
Chronotherapy in Hematological Malignancies: Evaluating the Rationale and Evidence
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.ABSTRACT Hematological malignancies remain one of the leading causes of morbidity and mortality despite advances in targeted therapies, immunotherapy, and stem cell transplantation. Emerging evidence indicates that treatment efficacy and toxicity depend not only on the choice of therapy but also on its timing relative to the patient's internal ...
Andrej Belančić +7 more
wiley +1 more source
Targeting opportunities presented by the pyrimidine biosynthesis pathway in Mycobacterium tuberculosis: a brief review. [PDF]
Biochem Soc TransAlberti M, Miggiano R.
europepmc +1 more source
The Structure of Vertebrate Antigen Receptor Repertoires: An Evolutionary Perspective
Immunological Reviews, Volume 341, Issue 1, August 2026.ABSTRACT In vertebrate adaptive immune systems, somatically diversified antigen receptors assume a central role in self/nonself discrimination. Attesting to the presence of a unique but unknown selective environment at early stages of vertebrate evolution, this facility emerged twice, in the ancestors of jawless and jawed vertebrates.
Thomas Boehm, Orlando B. Giorgetti
wiley +1 more source
The role of PAQR3 in cancer progression - Molecular regulation, signaling pathways, and clinical implications: A review. [PDF]
Biomol BiomedLv Y, Li D, Ren XF, Guo Q, Ren QY.
europepmc +1 more source
Inosine monophosphate dehydrogenases are key players for functional development in Arabidopsis
The Plant Journal, Volume 127, Issue 3, August 2026.SUMMARY In plants, nucleotide de novo synthesis is required throughout development to provide building blocks for the synthesis of DNA, RNA and nucleotide‐derived cofactors. Inosine Monophosphate Dehydrogenases (IMPDH) are key enzymes in de novo guanylate synthesis.
Eva Dörfer +10 more
wiley +1 more source
Effective Reduction in Nuclear DNA Contamination Allows Sensitive Mitochondrial DNA Methylation Determination by LC-MS/MS. [PDF]
Int J Mol SciLiang L +10 more
europepmc +1 more source
ChemBioChem, Volume 27, Issue 13, 14 July 2026.Clickable nucleoside phosphoramidites can be incorporated into oligonucleotides via solid‐phase synthesis (SPOS), enabling rapid and site‐specific post‐functionalization using bioorthogonal reactions. This review highlights their design, synthetic accessibility, and SPOS incorporation requirements, along with the kinetics and efficiency of post ...
Sébastien Depienne +3 more
wiley +1 more source