Journal of Chemistry, Volume 2016, Issue 1, 2016., 2016 We present the synthesis of 2‐ferrocenylbenzoic acid (FcOH) and its electrochemical and spectroscopic characterization. FcOH was characterized for interaction with DNA using theoretical and experimental methods. UV‐visible spectroscopy and cyclic voltammeter (CV) were used for the experimental account of FcOH‐DNA complex.
Ataf Ali Altaf +6 more
wiley +1 more source
Systematic site-directed mutagenesis to characterize subunit interactions in E. coli asparaginase II, an enzyme [PDF]
, 2005 L-asparaginases (EC 3.5.1.1) catalyze the hydrolysis of L-asparagine to aspartic acid and ammonia. Asparaginases of bacterial origin have been used for over 40 years in the treatment of acute lymphatic leukemia (ALL).
Röhm, Klaus-Heinrich (Prof.) +1 more
core +1 more source
Probing Retroviral and Retrotransposon Genome Structures: The “SHAPE” of Things to Come [PDF]
, 2012 Understanding the nuances of RNA structure as they pertain to biological function remains a formidable challenge for retrovirus research and development of RNA-based therapeutics, an area of particular importance with respect to combating HIV infection ...
Le Grice, Stuart F. J. +1 more
core +3 more sources
Tracing and tracking epiallele families in complex DNA populations [PDF]
, 2020 DNA methylation is a stable epigenetic modification, extremely polymorphic and driven by stochastic and deterministic events. Most of the current techniques used to analyse methylated sequences identify methylated cytosines (mCpGs) at a single-nucleotide
Alfonso Tramontano +8 more
core +1 more source
Nucleobase Protection of Deoxyribo‐ and Ribonucleosides [PDF]
, 2000 Protecting groups for the imide/lactam function of thymine/uracil and guanine, respectively, prevent irreversible nucleobase modifications that may occur in the presence of alkylating or condensing reagents that are commonly used in nucleoside protection
Iyer, Radhakrishnan P.
core +1 more source
Early-Phase Drive to the Precursor Pool: Chloroviruses Dive into the Deep End of Nucleotide Metabolism [PDF]
, 2023 Viruses face many challenges on their road to successful replication, and they meet those challenges by reprogramming the intracellular environment. Two major issues challenging Paramecium bursaria chlorella virus 1 (PBCV-1, genus Chlorovirus, family ...
Agarkova, Irina +4 more
core +1 more source
The relevance of covalent binding to mouse liver DNA to the carcinogenic action of hexachlorocyclohexane isomers [PDF]
, 2017 [3H]Hexachlorocyclohexane (HCH) was synthesized by chlorination of [3H]benzene prepared by catalytic tritiation of benzene with tritiated water. The isomers of HCH were separated by adsorption chromatography on silica gel.
Lutz, Werner K. +2 more
core
Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors [PDF]
, 2016 The natural product α-hydroxytropolones manicol and β-thujaplicinol inhibit replication of herpes simplex viruses 1 and 2 (HSV-1 and HSV-2, respectively) at nontoxic concentrations.
Baines, Joel D. +12 more
core +2 more sources
Coordinate suppression of mutations caused by Robertson's mutator transposons in maize [PDF]
, 1994 Transposable elements from the Robertson's Mutator family are highly active insertional mutagens in maize. However, mutations caused by the insertion of responder (non-autonomous) elements frequently depend on the presence of active regulator (autonomous)
Martienssen, R., Baron, A.
core
The Importance of Ile716 toward the Mutagenicity of 8-Oxo-2’-deoxyguanosine with Bacillus Fragment DNA Polymerase [PDF]
, 2020 8-oxo-2’-deoxyguanosine (OdG) is a prominent DNA lesion that can direct the incorporation of dCTP or dATP during replication. As the latter reaction can lead to mutation, the ratio of dCTP/dATP incorporation can significantly affect the mutagenic ...
Garcia, Anarosa A. +7 more
core +1 more source