Results 21 to 30 of about 69,682 (133)

Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism [PDF]

, 2011
To be viable, organisms possess a number of (deoxy)nucleotide phosphohydrolases, which hydrolyze these nucleotides removing them from the active NTP and dNTP pools. Deamination of purine bases can result in accumulation of such nucleotides as ITP, dITP,
Davies, Oluwafemi, Mendes, Pedro, Naglis Malys, Smallbone, Kieran, Pedro Mendes, Malys, Naglis, Smallbone, Kiera, Kieran Smallbone, Oluwafemi Davies   +8 more
core   +1 more source

Single‐base methylome profiling of the giant kelp Saccharina japonica reveals significant differences in DNA methylation to microalgae and plants

New Phytologist, Volume 225, Issue 1, Page 234-249, January 2020., 2020
Summary Brown algae have convergently evolved plant‐like body plans and reproductive cycles, which in plants are controlled by differential DNA methylation. This contribution provides the first single‐base methylome profiles of haploid gametophytes and diploid sporophytes of a multicellular alga. Although only c.
Xiao Fan, Wentao Han, Linhong Teng, Peng Jiang, Xiaowen Zhang, Dong Xu, Chang Li, Matteo Pellegrini, Chunhui Wu, Yitao Wang, Michelle Joyce Slade Kaczurowski, Xin Lin, Leila Tirichine, Thomas Mock, Naihao Ye   +14 more
wiley   +1 more source

Development of a machine learning potential for nucleotides in water [PDF]

, 2022
Recent experimental research showed that nucleotides, under favorable conditions of temperature and concentration, can self-assemble into liquid crystals. The mechanism involves the stacking of nucleotides into columnar aggregates. It has been proposed
Martina, Riccardo
core  

The effect of extracellular nucleotides on cytokine production and phagocytosis of macrophages [PDF]

, 2014
Bacterial sepsis is a severe clinical condition, leading to severe sepsis, septic shock, and death. The complex pathophysiology of sepsis is not yet fully understood.
Hänsli, Christof Karl
core   +2 more sources

Extracellular Nucleotides in the Regulation of Kidney Functions

, 2013
ATP is normally regarded as the major source of fuel for the energy-demanding processes within cells; however, ATP and other nucleotides (such as ADP, UTP, UDP) can be released from cells, where they act as autocrine or paracrine signaling molecules to ...
Kishore, Bellamkonda, Volker Vallon, Unwin, Robert, Wildman, Scott S.P., Prætorius, Helle, Robert John Unwin, Vallon, Volker, Helle Praetorius, Bellamkonda K Kishore   +8 more
core   +1 more source

Contribution of DNA/RNA Structures Formed by Expanded CGG/CCG Repeats Within the FMR1 Locus in the Pathogenesis of Fragile X‐Associated Disorders

WIREs RNA, Volume 15, Issue 6, November/December 2024.
CGG repeat expansion may occur in the 5′ untranslated region of the FMR1 gene. The resulting mutant DNA and RNA with expanded CGG repeats form stable secondary structures that can interfere with numerous cellular processes. Depending on the length of the CGG repeats, different molecular phenotypes may occur, which in turn determine different clinical ...
Izabela Broniarek, Daria Niewiadomska, Krzysztof Sobczak   +2 more
wiley   +1 more source

Sulforaphane‐induced metabolomic responses with epigenetic changes in estrogen receptor positive breast cancer cells

FEBS Open Bio, Volume 8, Issue 12, Page 2022-2034, December 2018., 2018
Sulforaphane (SFN) may be a promising chemopreventive agent. We investigated the metabolic profiles of MCF‐7 cells with estrogen (E2) and/or SFN treatment by GC‐MS and UPLC‐Orbitrap‐MS methods. The data showed that SFN can reverse the E2‐induced changes in amino acid, purine, and folic acid metabolism, as well as glycolysis and energy metabolism, and ...
Shuyuan Cao, Li Wang, Zhan Zhang, Feng Chen, Qian Wu, Lei Li   +5 more
wiley   +1 more source

Analysis of Nucleosides and Nucleotides in Milk and Infant Formula [PDF]

, 2013
Nucleotides have been routinely supplemented to infant formulas due to the important roles they play in metabolism and to replicate the higher concentrations typically found in human milk.
Gill, Brendon D.
core  

On the chemistry of sunlight‐induced DNA lesions: A perspective on the alkaline chemical‐induced reactivities of photo‐damaged pyrimidine intra‐strand dimers

Photochemistry and Photobiology, Volume 100, Issue 6, Page 1698-1712, November/December 2024.
UV photoexcitation of adjacent intra‐strand pyrimidines in DNA can promote their covalent dimerization at sites such as 5′‐T‐p‐T‐3′ and 5′‐T‐p‐C‐3′. This photo‐reactivity leads, notably, to cyclobutane pyrimidine dimers, pyrimidine (6‐4) pyrimidone photoproducts (6‐4PPs), and, in bacterial endospores, the spore photoproduct, SP.
Ritu Chaturvedi, Eric C. Long
wiley   +1 more source

Risks for public health related to the presence of furan and methylfurans in food

EFSA Journal, Volume 15, Issue 10, October 2017., 2017
Abstract The European Commission asked EFSA for a scientific evaluation on the risk to human health of the presence of furan and methylfurans (2‐methylfuran, 3‐methylfuran and 2,5‐dimethylfuran) in food. They are formed in foods during thermal processing and can co‐occur.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Jan Alexander, Lars Barregård, Margherita Bignami, Beat Brüschweiler, Sandra Ceccatelli, Bruce Cottrill, Michael Dinovi, Lutz Edler, Bettina Grasl‐Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Carlo Stefano Nebbia, Isabelle P Oswald, Annette Petersen, Martin Rose, Alain‐Claude Roudot, Tanja Schwerdtle, Christiane Vleminckx, Günter Vollmer, Kevin Chipman, Bruno De Meulenaer, Michael Dinovi, Wim Mennes, Josef Schlatter, Dieter Schrenk, Katleen Baert, Bruno Dujardin, Heather Wallace   +29 more
wiley   +1 more source