RNA polymerisation without catalyst from 2’,3’-cyclic nucleotides by drying at air-water interfaces [PDF]
, 2022 For the emergence of life, the abiotic synthesis of RNA from its monomers is a central step. We found alkaline, uncatalysed drying conditions in bulk and at heated air-water interfaces where 2´,3´-cyclic nucleotides polymerised, forming up to 10-mers ...
Sreekar, Wunnava +16 more
core +2 more sources
Cerium Phosphate-Assisted Formation of Nucleosides and Nucleotides from Formamide in a One-Pot (Photo)catalytic Reaction [PDF]
, 2023 The abiotic formation of nucleotides from small, simple molecules is of large interest in the context of elucidating the origin of life scenario. In what follows it is shown that nucleosides and nucleotides can be formed from formamide in a one-pot ...
Nitai, Arbell +3 more
core +2 more sources
Kinetic and NMR spectroscopic study of the Chemical Stability and Reaction Pathways of Sugar Nucleotides [PDF]
, 2022 The alkaline cleavage of two types of sugar nucleotides has been studied by 1H and 31P NMR in order to obtain information on the stability and decomposition pathways in in aqueous solutions under alkaline conditions.
Korhonen Heidi +5 more
core +1 more source
Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC [PDF]
, 2012 Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and pathophysiological responses through paracrine and autocrine signalling pathways.
Claire M. Peppiatt-Wildman +18 more
core +1 more source
Guanosine nucleotides regulate B2 kinin receptor affinity of agonists but not of antagonists: Discussion of a model proposing receptor precoupling to G protein [PDF]
, 2000 The effect of nucleotides on binding of the B2 kinin (BK) receptor agonist {[}H-3]BK and the antagonist {[}H-3]NPC17731 to particulate fractions of human foreskin fibroblasts was studied.
Er Faussner +3 more
core +1 more source
HPLC analysis of nucleotides [PDF]
, 2017 This project developed a novel hydrophilic interaction chromatography method for the detection and identification of nucleotides. The method was validated by testing biological specimens; adult and neonatal saliva, and red and white blood cell extracts ...
Narayan, Vicrant S.
core +1 more source
CSF concentrations of cAMP and cGMP are lower in patients with Creutzfeldt-Jakob disease but not Parkinson's disease and amyotrophic lateral sclerosis. [PDF]
, 2012 The cyclic nucleotides cyclic adenosine-3',5'-monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) are important second messengers and are potential biomarkers for Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and ...
Oeckl, Patrick +23 more
core +1 more source
Survey of ribose ring pucker of signaling nucleosides and nucleotides [PDF]
, 2020 The ribose of protein-bound nucleosides and nucleotides displays preferred conformations (usually either North or South), which can be exploited to design enhanced analogs having chemically fixed conformations.
Jacobson K. A., Salmaso V.
core +1 more source
Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]
, 2005 Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Chootip, Krongkarn +2 more
core +5 more sources
Functionalized Nanogap for DNA Read‐Out: Nucleotide Rotation and Current‐Voltage Curves
ChemPhysChem, Volume 21, Issue 18, Page 2068-2074, September 15, 2020., 2020 An applied voltage bias across a nanogap opened by diamondoid‐functionalized electrodes can be used to detect the identity of DNA nucleotides. For the detection, the different rotations of the DNA inside the nanogap control the exact value of the electronic current used for the detection.
Frank C. Maier, Maria Fyta
wiley +1 more source