Results 31 to 40 of about 69,682 (133)
Chemistry – A European Journal, Volume 30, Issue 49, September 2, 2024.The mutagenic etheno adduct of guanine exhibits a peculiar behavior of its lowest singlet excited state. The two independent and short‐lived emission bands revealed by femtosecond upconversion fluorescence are associated with two strongly coupled bright minima of different geometry.
Paloma Lizondo‐Aranda +4 more
wiley +1 more source
Multiscale Systems‐Pharmacology Pipeline to Assess the Prophylactic Efficacy of NRTIs Against HIV‐1
CPT: Pharmacometrics &Systems Pharmacology, Volume 5, Issue 7, Page 377-387, July 2016., 2016 While HIV‐1 continues to spread, the use of antivirals in preexposure prophylaxis (PrEP) has recently been suggested. Here we present a modular systems pharmacology modeling pipeline, predicting PrEP efficacy of nucleotide reverse transcriptase inhibitors (NRTIs) at the scale of reverse transcription, target‐cell, and systemic infection and after ...
S Duwal, V Sunkara, M von Kleist
wiley +1 more source
Multiple Factors Determine the Oncolytic or Carcinogenic Effects of TLRs Activation in Cancer
Journal of Immunology Research, Volume 2024, Issue 1, 2024.Toll‐like receptors (TLRs) belong to a germline‐encoded protein family. These are pattern recognition receptors. They sense pathogen‐associated molecular patterns (PAMPs). When this occurs, activation of the NF‐ĸB pathway follows. This triggers the innate immune response of the host.
Yingxiang Yang +4 more
wiley +1 more source
Journal of Chemistry, Volume 2016, Issue 1, 2016., 2016 We present the synthesis of 2‐ferrocenylbenzoic acid (FcOH) and its electrochemical and spectroscopic characterization. FcOH was characterized for interaction with DNA using theoretical and experimental methods. UV‐visible spectroscopy and cyclic voltammeter (CV) were used for the experimental account of FcOH‐DNA complex.
Ataf Ali Altaf +6 more
wiley +1 more source
Supplementation of Nucleotides to Enhance Performance and Immune Responses of Asian Seabass [PDF]
, 2021 Supplementation of nucleotides into fish diets can be an alternative method to manage disease problems in aquaculture, since it was reported could improve the growth rate and immunity of some aquaculture species. The present study assessed the growth and
Glencross, Brett +5 more
core
Modified Nucleotides for Discrimination between Cytosine and the Epigenetic Marker 5‐Methylcytosine
, 2016 5-Methyl-2'-deoxycytosine, the most common epigenetic marker of DNA in eukaryotic cells, plays a key role in gene regulation and affects various cellular processes such as development and carcinogenesis.
Janina von Watzdorf +5 more
core +1 more source
Profile of Nucleosides and Nucleotides in Donkey's Milk.
, 2014 Nucleotides play a crucial role to cellular functions; they can be obtained from the diet or through the nucleotide salvage pathway, however, in particular situations (occurring mainly in newborns) the metabolic demand of nucleotides exceeds the capacity
POLIDORI, Paolo +5 more
core +1 more source
Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides [PDF]
, 1989 Human neutrophils and HL-60 leukaemic cells possess an NADPH oxidase which catalyses superoxide (O2-) formation and is activated by the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe).
Seifert, Roland +2 more
core +1 more source
Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine [PDF]
, 2012 Background: Purine nucleotides exhibit various functions in cellular metabolism. Besides serving as building blocks for nucleic acid synthesis, they participate in signaling pathways and energy metabolism.
Sarah Zimmet +11 more
core +1 more source
, 1972 PEPTIDYL-DONOR SUBSTRATES FOR RIBOSOMAL PEPTIDYL TRANSFERASE - CHEMICAL SYNTHESIS AND BIOLOGICAL-ACTIVITY OF N-ACETYL AMINOACYL DI-NUCLEOTIDES AND TRI ...
Julian Mercer (13076475) +1 more
core +1 more source