Results 1 to 10 of about 24,707 (148)

Suppression of Ehrlich ascites tumor cell proliferation via G1 arrest induced by dietary nucleic acid-derived nucleosides. [PDF]

PLoS ONE
The nucleic acids found in food play a crucial role in maintaining various bodily functions. This study investigated the potential anticancer effects of dietary nucleic acids, an area that is still not fully understood.
Nahoko Shiomi, Mamia Furuta, Yutaro Sasaki, Isao Matsui-Yuasa, Keisuke Kiriyama, Mica Fujita, Keita Sutoh, Akiko Kojima-Yuasa   +7 more
doaj   +2 more sources

Staphylococcus aureus Multiplexes Death-Effector Deoxyribonucleosides to Neutralize Phagocytes

Frontiers in Immunology, 2022
Adenosine synthase A (AdsA) is a key virulence factor of Staphylococcus aureus, a dangerous microbe that causes fatal diseases in humans. Together with staphylococcal nuclease, AdsA generates deoxyadenosine (dAdo) from neutrophil extracellular DNA traps ...
Eshraq Tantawy, Eshraq Tantawy, Nicoletta Schwermann, Nicoletta Schwermann, Tjorven Ostermeier, Tjorven Ostermeier, Annette Garbe, Heike Bähre, Marius Vital, Volker Winstel, Volker Winstel   +10 more
doaj   +1 more source

Molecular Identification of the Transient Species Mediating the Deactivation Dynamics of Solvated Guanosine and Deazaguanosine

Molecules, 2022
Small structural alterations of the purine/pyrimidine core have been related to important photophysical changes, such as the loss of photostability. Similarly to canonical nucleobases, solute-solvent interactions can lead to a change in the excited state
Javier Ortín-Fernández, Jesús González-Vázquez, Lara Martínez-Fernández, Inés Corral   +3 more
doaj   +1 more source

The Status of Antioxidants and Oxidative Damage in Patients with COVID-19

Ahi Evran Medical Journal, 2023
Purpose: COVID-19 is a viral disease that has recently caused a pandemic and significantly affects human health. In this study, superoxide dismutase, glutathione peroxidase, glutathione, total thiol, natural thiol, disulfide, oxidative DNA damage and ...
İrfan BİNİCİ, Hamit Hakan ALP, Zübeyir HUYUT, Esra GÜRBÜZ, Hülya GÜNBATAR, Şükrü AKMEŞE, Mustafa Kasım KARAHOCAGİL, Halil İbrahim AKBAY   +7 more
doaj   +1 more source

Deoxyguanosine kinase deficiency and recurrent spontaneous pneumothorax: a case report

Journal of Medical Case Reports, 2023
Background Deoxyguanosine kinase deficiency is mainly manifested by hepatic and neurological damage, hence it belongs to the hepatocerebral form of mitochondrial deoxyribonucleic acid depletion syndrome.
Alice Ramboux, Alain Poncelet, Philippe Clapuyt, Isabelle Scheers, Etienne Sokal, Raymond Reding, Xavier Stephenne   +6 more
doaj   +1 more source

8-Fluoro-N-2-Isobutyryl-2′-Deoxyguanosine: Synthesis and Reactivity

Molbank, 2020
3′,5′-O-Bis(tert-butyldimethylsilyl)-8-fluoro-N-2-isobutyryl-2′-deoxyguanosine was synthesized from 3′,5′-O-bis(tert-butyldimethylsilyl)-N-2-isobutyryl-2′-deoxyguanosine by the treatment with N-fluorobenzenesulfonimide.
Andrei Solodinin, James Helmkay, Samuel Ollivier, Hongbin Yan   +3 more
doaj   +1 more source

Widely targeted metabolomics reveals the antioxidant and anticancer activities of different colors of Dianthus caryophyllus

Frontiers in Nutrition, 2023
Carnation is edible flower that has potent antioxidant properties and is used in traditional Chinese medicinal system and food industry. The phytochemicals responsible for these various proprieties, however, are not fully understood.
Xuhong Zhou, Xuhong Zhou, Miaomaio Wang, Hong Li, Shilong Ye, Wenru Tang   +5 more
doaj   +1 more source

OxiDIP-Seq for Genome-wide Mapping of Damaged DNA Containing 8-Oxo-2'-Deoxyguanosine

Bio-Protocol, 2022
8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) is considered to be a premutagenic DNA lesion generated by 2'-deoxyguanosine (dG) oxidation due to reactive oxygen species (ROS).
Francesca Gorini, Giovanni Scala, Susanna Ambrosio, Barbara Majello, Stefano Amente   +4 more
doaj   +1 more source

Incorporation characteristics of exogenous 15N-labeled thymidine, deoxyadenosine, deoxyguanosine and deoxycytidine into bacterial DNA.

PLoS ONE, 2020
Bacterial production has been often estimated from DNA synthesis rates by using tritium-labeled thymidine. Some bacteria species cannot incorporate extracellular thymidine into their DNA, suggesting their biomass production might be overlooked when using
Kenji Tsuchiya, Tomoharu Sano, Noriko Tomioka, Ayato Kohzu, Kazuhiro Komatsu, Ryuichiro Shinohara, Shinji Shimode, Tatsuki Toda, Akio Imai   +8 more
doaj   +1 more source

8-Oxo-7,8-Dihydro-2′-Deoxyguanosine (8-oxodG) and 8-Hydroxy-2′-Deoxyguanosine (8-OHdG) as a Potential Biomarker for Gestational Diabetes Mellitus (GDM) Development

Molecules, 2020
The growing clinical and epidemiological significance of gestational diabetes mellitus results from its constantly increasing worldwide prevalence, obesity, and overall unhealthy lifestyle among women of childbearing age. Oxidative stress seems to be the
Sandra K. Urbaniak, Karolina Boguszewska, Michał Szewczuk, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski   +4 more
doaj   +1 more source