Results 11 to 20 of about 53,334 (334)

Association of sirtuin 1 rs10997868 and rs730821 polymorphisms with sirtuin 1 and hydroxy-2′-deoxyguanosine levels in healthy smokers: A case–control study [PDF]

Journal of International Medical Research
Objectives This case–control study explored the association of sirtuin 1 polymorphisms (rs10997868 and rs730821) with metabolic parameters, smoking duration, sirtuin 1 levels, and the oxidative stress biomarker 8-hydroxy-2′-deoxyguanosine in healthy ...
Samar Sultan
doaj   +2 more sources

Synthesis of C8-alkylamino substituted 2'-deoxyguanosine [PDF]

Nucleic Acids Symposium Series, 2007
Synthesis of C8-alkynyl- and alkylamino substituted 2'-deoxyguanosine is described. Protected alkynylamines are coupled with 8-bromo-2'-deoxyguanosine by a Pd(0)-mediate Sonogashira coupling protocol. Hydrogenation of alkynyl derivatives over 10% Pd/C under atmospheric pressure gave 8-alkylamino guanosine derivatives in nearly quantitative yields.
Yoshio Saitō, Katsuhiko Matsumoto, S. S. Bag, Shinzi Ogasawara, Iwao Suzuka, Isao Saito   +5 more
openalex   +3 more sources

Temperature stability of urinary F2-isoprostane and 8-hydroxy-2′-deoxyguanosine

Practical Laboratory Medicine
Background: Clinical and epidemiological studies employ long-term temperature storage but the effect of temperature on the stability of oxidative stress (OS) markers is unknown.
Katarzyna Kordas, Diala Ghazal, Elena I. Queirolo, James R. Olson, María Inés Beledo, Richard W. Browne   +5 more
doaj   +2 more sources

8-Oxo-7,8-dihydro-2'-deoxyguanosine Forms a Relatively Unstable Tetrameric Structure Compared with 2'-Deoxyguanosine

Journal of Clinical Biochemistry and Nutrition, 2009
The hydrogen-bonded guanine tetrad, or G-quartet has been implicated in a variety of biological roles, including the function of chromosome telomeres. Here effect of the hydroxylation of guanosine at the 8 position on the G-quartet formation was examined.
Hideo Iwahashi
openalex   +4 more sources

Determining 8-oxo-2’-deoxyguanosine/2’-deoxyguanosine ratio in DNA by reverse phase HPLC combined with amperometric detection

Тонкие химические технологии, 2010
The article presents an optimized method for the determination of the ratio of 8-oxo-2'-deoxyguanosine (formed in DNA due to the action of active forms of oxygen) to 2'-deoxyguanosine.
D. S. Esipov, E. V. Sidorenko, O. V. Esipova, T. A. Gorbacheva, T. S. Nevredimova, A. L. Krushinskiy, V. S. Kuzenkov, V. P. Reutov   +7 more
doaj   +1 more source

In-Vitro Study of DNA Adduct 8-Hydroxy-2’-Deoxyguanosine Formation from 2’-Dexoyguanosine Exposure Against Benzo[a]pyrene and Ni(II) Compounds Through Fenton-Like Reactions

, 2019
Oxidative damage to DNA can lead to cancer, aging, and neurological disorders. Of the four DNA bases, guanine is the most susceptible to oxidation. To help us further our knowledge of how oxidation contributes to illness and disease, it is important to study the oxidation process and products of 2'-deoxyguanosine (2'-dG). The oxidation product of 2'-dG,
Ikko Haidar Farozy, Sri Handayani, B. Budiawan, Intan Cahaya Dani   +3 more
openalex   +2 more sources

Predictive value of 8-hydroxy-2'-deoxyguanosine and 8-nitroguanine production in radiation-induced skin damage after postoperative breast cancer radiotherapy. [PDF]

Explor Target Antitumor Ther
Verigos EK, Sagredou S, Verigos KE, Orfanakos K, Alifieris CE, Deligiorgi MV, Dalezis P, Panayiotidis MI, Karamanakos PN, Trafalis DT.   +9 more
europepmc   +3 more sources

Staphylococcus aureus Multiplexes Death-Effector Deoxyribonucleosides to Neutralize Phagocytes

Frontiers in Immunology, 2022
Adenosine synthase A (AdsA) is a key virulence factor of Staphylococcus aureus, a dangerous microbe that causes fatal diseases in humans. Together with staphylococcal nuclease, AdsA generates deoxyadenosine (dAdo) from neutrophil extracellular DNA traps ...
Eshraq Tantawy, Eshraq Tantawy, Nicoletta Schwermann, Nicoletta Schwermann, Tjorven Ostermeier, Tjorven Ostermeier, Annette Garbe, Heike Bähre, Marius Vital, Volker Winstel, Volker Winstel   +10 more
doaj   +1 more source

Molecular Identification of the Transient Species Mediating the Deactivation Dynamics of Solvated Guanosine and Deazaguanosine

Molecules, 2022
Small structural alterations of the purine/pyrimidine core have been related to important photophysical changes, such as the loss of photostability. Similarly to canonical nucleobases, solute-solvent interactions can lead to a change in the excited state
Javier Ortín-Fernández, Jesús González-Vázquez, Lara Martínez-Fernández, Inés Corral   +3 more
doaj   +1 more source

The Status of Antioxidants and Oxidative Damage in Patients with COVID-19

Ahi Evran Medical Journal, 2023
Purpose: COVID-19 is a viral disease that has recently caused a pandemic and significantly affects human health. In this study, superoxide dismutase, glutathione peroxidase, glutathione, total thiol, natural thiol, disulfide, oxidative DNA damage and ...
İrfan BİNİCİ, Hamit Hakan ALP, Zübeyir HUYUT, Esra GÜRBÜZ, Hülya GÜNBATAR, Şükrü AKMEŞE, Mustafa Kasım KARAHOCAGİL, Halil İbrahim AKBAY   +7 more
doaj   +1 more source