Results 211 to 220 of about 47,583 (239)

Solution Structure of a DNA Duplex Containing 8-Hydroxy-2′-Deoxyguanosine Opposite Deoxyguanosine

Journal of Molecular Biology, 2003
Deoxyguanosine residues are hydroxylated by reactive oxygen species at the C-8 position to form 8-hydroxy-2'-deoxyguanosine (8-OG), one of the most important mutagenic lesions in DNA. Though the spontaneous G:C to C:G transversions are rare events, the pathways leading to this mutation are not established.
Varatharasa Thiviyanathan, David G. Gorenstein, Tapas K. Hazra, Anoma Somasunderam, Sankar Mitra   +4 more
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Phosphorylation of deoxyguanosine in intact and fractured mitochondria

Molecular and Cellular Biochemistry, 1987
The phosphorylation of deoxyguanosine was measured in fractured and intact mitochondria and an apparent Km of 16 microM for deoxyguanosine was calculated using fractured mitochondria. The effects of various deoxynucleotides on the phosphorylating activity in fractured organelles was tested at both a high and low ratio of NXP/ATP and at two pH values, 7.
Linda F. Watkins, Roger A. Lewis
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Reactions of ethyleneimine with guanosine and deoxyguanosine

Chemico-Biological Interactions, 1984
Ethyleneimine was reacted with guanosine in aqueous medium and the products were purified by Sephadex G-10 and high-performance liquid chromatography (HPLC). Two products were identified by UV-spectroscopy: imidazole-ring opened 7-alkylguanosine and 1-alkylguanosine, accounting for 80% and 14% of all adduct radioactivity, respectively.
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Nitrogen Dioxide as an Oxidizing Agent of 8-Oxo-7,8-dihydro-2‘-deoxyguanosine but Not of 2‘-Deoxyguanosine

Chemical Research in Toxicology, 2001
The redox reactions of guanine and its widely studied oxidation product, the 8-oxo-7,8-dihydro derivative, are of significant importance for understanding the mechanisms of oxidative damage in DNA. Employing 2'-deoxyguanosine 5'-monophosphate (dGMP) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) in neutral aqueous solutions as model systems, we ...
and Alexander Dourandin, Didier Gasparutto, Nicholas E. Geacintov, Vladimir Shafirovich, Jean Cadet   +4 more
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Reaction of 2′‐Deoxyguanosine with Glyceraldehyde

Liebigs Annalen der Chemie, 1994
AbstractReaction of 2′‐deoxyguanosine with glyceraldehyde under physiological conditions leads to the formation of ammonium 2‐[9‐(2‐deoxy‐β‐D‐ribofuranosyl)‐6,9‐dihydro‐6‐oxo‐1H‐purin‐2‐ylamino]propionate (8). The same substance can be detected in 2′‐deoxyguanosine/glucose reaction mixtures as minor product.
Stefan Ochs, Theodor Severin
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Antibodies specific to deoxyguanosine 5′-phosphate

Molecular Immunology, 1980
Abstract Antibodies to deoxyguanosine 5′-phosphate were produced in rabbits using a bovine serum albumin conjugate of the nucleotide. The presence of hapten-specific antibodies in the antisera was shown by double diffusion in agar and the quantitative precipitin reaction. The specificity of the antibodies was determined by measuring the inhibition of
K. Jayaraman, T.M. Jacob
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Alkylation of deoxyguanosine by the sesquiterpene lactone hymenoxon

Toxicology Letters, 1985
Hymenoxon, a toxic sesquiterpene lactone found in the ruminant forage plant Hymenoxys odorata, binds deoxyguanosine in a cell-free system, and forms adducted guanine residues in sheep lymphocyte DNA. Mitogen-stimulated DNA synthesis in lymphocytes was inhibited by hymenoxon at concentrations greater than 100 microM.
Sylvia, VL, Joe, CO Joe, Cheol O, Stipanovic, RD, Kim, HL, Busbee, DL   +4 more
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Inhibition of plant cytokinesis by deoxyguanosine and caffeine

Plant Cell Reports, 1983
The efficacy of 2'-deoxyguanosine (GdR) on the induction of binucleate cells in onion root tips was studied. GdR inhibits plant cytokinesis during the last part of the mitotic period. Apparently, this deoxynucleoside causes a considerable slowing down in the mitotic rate (50%) and also has a slight effect as an inhibitor of cytokinesis (30%).
M. C. Carmona, J. Becerra
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Synthesis and characterization of deoxyguanosine–benzoquinone adducts

Journal of Applied Toxicology, 1990
AbstractBenzene expresses its carcinogenic potential in humans largely in the form of acute leukemia. Because an understanding of the formation of DNA adducts by benzene metabolites may help to explain the etiologkal role they play in benzene‐induced bone marrow disease, we have synthesized, isolated and characterized adducts formed by the reaction of ...
George F. Kalf, Gisela Witz, Robert Snyder, Stephen A. Winkle, Lubow Jowa   +4 more
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Unexpected Transposition of a Deoxyguanosine Derivative

Nucleosides and Nucleotides, 1987
Abstract The synthesis of a tricyclic deoxynucleoside by reaction of β-substituted ethanols with an activated deoxyguanosine is described. Its formation is rationnalised by an 06-N1-transposition.
Jean-Louis Imbach, J. L. Barascut, M. Lucas, A.-F. Maggio   +3 more
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