Results 221 to 230 of about 47,583 (239)

Molecular conformation of deoxyguanosine 5′-phosphate

Nature, 1974
THE allowed conformations of nucleic acids depend on the flexibility of the structure of the nucleotides from which they are constructed. Many X-ray crystallographic studies of the degree of flexibility of these structures have shown that nucleosides exhibit a larger number of preferred conformations than nucleotides, and this led Sundaralingam1 to ...
H. R. Wilson, P. Tollin, D. W. Young
openaire   +3 more sources

Phosphorylation of Deoxyguanosine in Rat Liver Mitochondria

1984
Recent studies document that mitochondria from mouse skin (1), human lung fibroblasts (2) and calf thymus (3) contain a deoxyguanosine (dG) kinase which is distinctly different from that found in the cytosol. A preliminary report (4) has shown that dG is taken up by intact, respiring rat liver mitochondria by a carrier mediated process.
Roger A. Lewis, Linda F. Watkins
openaire   +3 more sources

The reaction of melphalan with deoxyguanosine and deoxyguanylic acid

Chemico-Biological Interactions, 1992
The reaction of melphalan (phenylalanine mustard, I) with 2'-deoxyguanosine, followed by removal of the sugar in acid, yielded two products. The major product was identified as 4-(N-(2-guanin-7-ylethyl)-N-(2-hydroxyethyl)amino)phenyl- alanine (II) by ultra-violet absorption, mass and NMR spectroscopy.
Martin R. Osborne, P. D. Lawley
openaire   +3 more sources

Hydroxyl-specific fluorescence labeling of ABP-deoxyguanosine, PhIP-deoxyguanosine, and AFB1-formamidopyrimidine with BODIPY-FL

Analytical Biochemistry, 2006
Detection and analysis of DNA adducts resulting from endogenous or exogenous exposures to carcinogens are essential not only for quantifying biologically effective doses but also for establishing relationships between exposure and cancer risk. We have developed and validated a procedure of high sensitivity and specificity based on fluorescence labeling
Hyun Gyung Jang, Gerald N. Wogan, John S. Wishnok, Misun Park, Steven R. Tannenbaum   +4 more
openaire   +3 more sources

8-Hydroxy-2′-deoxyguanosine formation during the catalytic oxidation of hydrazines in the presence of 2′-deoxyguanosine

Chemico-Biological Interactions, 1991
The reaction of 2'-deoxyguanosine (1), substituted hydrazines (Hy) and oxygen, in the presence of Cu(II) as catalyst, yields 8-hydroxy-2'-deoxyguanosine (2). The rate of formation of 2 was found to be dependent upon the oxidation potential of the Hy and on structural factors of the Hy.
Peter M. Gannett, Xianglin Shi, Bela Toth, Naresh S. Dalal   +3 more
openaire   +3 more sources

Reactions of Formaldehyde Plus Acetaldehyde with Deoxyguanosine and DNA:  Formation of Cyclic Deoxyguanosine Adducts and Formaldehyde Cross-Links

Chemical Research in Toxicology, 2003
We investigated the reactions of formaldehyde plus acetaldehyde with dGuo and DNA in order to determine whether certain 1,N(2)-propano-dGuo adducts could be formed. These adducts-3-(2'-deoxyribosyl)-5,6,7,8-tetrahydro-8-hydroxypyrimido[1,2-a]purine-(3H)-one (1) and 3-(2'-deoxyribosyl)-5,6,7,8-tetrahydro-6-hydroxypyrimido[1,2-a]purine-(3H)-one (3a,b ...
Cheng, G., Shi, Y., Sturla, S. J., Jalas, J. R., McIntee, Edward J., Villalta, P. W., Upadhyaya, P., Hecht, S. S.   +7 more
openaire   +3 more sources

An Adduct between Peroxynitrite and 2‘-Deoxyguanosine:  4,5-Dihydro-5-hydroxy-4-(nitrosooxy)-2‘-deoxyguanosine

Chemical Research in Toxicology, 1996
The reactivity of peroxynitrite (OONO-) with DNA is of interest because it is is released during chronic inflammation, a major contributor to cancer. Peroxynitrite was found to undergo homolytic addition to the C4-C5 double bond of 2'-deoxyguanosine with formation of 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine (nox-dG).
Douki, Thierry, Cadet, J., Ames, B. N.
openaire   +4 more sources

Characterization of a Deoxyguanosine Adduct of Tetrachlorobenzoquinone:  Dichlorobenzoquinone-1,N²-etheno-2‘-deoxyguanosine

Chemical Research in Toxicology, 2005
Pentachlorophenol (PCP), a widespread environmental pollutant that is possibly carcinogenic to humans, is metabolically oxidized to tetrachloroquinone. DNA adducts attributable to tetrachloroquinone have been observed previously in vitro and detected in vivo. In addition, an unidentified adduct in these studies coeluted with the product of the reaction
Peter W. Villalta, Shana J. Sturla, Philippe Bühlmann, Thu N. T. Nguyen, Anthony D. Bertagnolli   +4 more
openaire   +3 more sources

Mitsunobu Reaction of Protected Deoxyguanosine and Guanozine

HETEROCYCLES, 1984
AbstractDas geschützte Guanosin bzw. Desoxyguanosin (I) wird mit dem Alkohol (II) unter den Bedingungen der Mitsunobu‐Reaktion in O6‐Stellung blockiert.
Ramamurthy Charubala, Wolfgang Pfleiderer, Thomas Trichtinger   +2 more
openaire   +3 more sources

Deoxyguanosine kinase deficiency: a report of four patients

Journal of Pediatric Endocrinology and Metabolism, 2017
AbstractBackground:Hepatic involvement is a common feature in childhood mitochondrial disorders. Deoxyguanosine kinase (DGUOK) deficiency is one of the mitochondrial DNA depletion syndromes associated with hepatocerebral syndrome. Hepatic disease and neurologic dysfunction occurs within weeks after birth. Low birth weight is one of the common features.
Unal, ÖZLEM, DURSUN, ALİ, YÜCE, AYSEL, TOKATLI, AYŞEGÜL, KILIÇ, MUSTAFA, Sivri, Serap Hatice, COŞKUN, TURGAY, Gulsen, Hayriye Hizarcioglu, ÖZTÜRK HİŞMİ, BURCU   +8 more
openaire   +3 more sources