Highly Sensitive Electrochemical Sensor for the Determination of 8-Hydroxy-2 \u27-deoxyguanosine Incorporating SWCNTs-Nafion Composite Film [PDF]
, 2015 8-Hydroxy-2\u27-deoxyguanosine (8-OHdG) is a typical biomarker of oxidative DNA damage and has attracted much attention in recent years since the level of 8-OHdG in body fluids is typically associated with various diseases.
Gao, Qiang +5 more
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Redox Biology, 2016 The breast cancer 1 (brca1) gene is associated with breast and ovarian cancers, and heterozygous (+/−) brca1 knockout progeny develop normally, suggesting a negligible developmental impact.
Aaron M. Shapiro +2 more
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Salvage enzymes in nucleotide biosynthesis [PDF]
, 2007 Balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA, and ribonucleoside triphosphates (NTPs), the precursors of RNA, are crucial for a controlled cell proliferation.
Kosinska, Urszula
core
Contribution of MUTYH variants to male breast cancer risk: results from a multicenter study in Italy [PDF]
, 2018 Inherited mutations in BRCA1, and, mainly, BRCA2 genes are associated with increased risk of male breast cancer (MBC). Mutations in PALB2 and CHEK2 genes may also increase MBC risk.
Azzollini, Jacopo +25 more
core +3 more sources
Transverse Electronic Transport through DNA Nucleotides with Functionalized Graphene Electrodes
, 2012 Graphene nanogaps and nanopores show potential for the purpose of electrical DNA sequencing, in particular because single-base resolution appears to be readily achievable.
Agapito L. A. +68 more
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Analytics of oxidative stress markers in the early diagnosis of oxygen DNA damage [PDF]
, 2017 Under homeostatic conditions, an equilibrium state between amounts of free radicals formed and their scavenging is observed. Free radicals are destructive only when present in excess.
Dabrowska, Natalia, Wiczkowski, Andrzej
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Molbank, 2007 In this manuscript we report on the regioselective electrophilic substitution at C(7) of 7-[2-deoxy-3,5-bis-O-(2-methylpropanoyl)-ß-D-erythro-pentofuranosyl]-2-(formylamino)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine (2) – a protected precursor of 7-deaza-2 ...
Helmut Rosemeyer, Natalya Ramzaeva
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Enzymatic Cleavage of Deoxyguanosine Triphosphate to Deoxyguanosine and Tripolyphosphate [PDF]
Journal of Biological Chemistry, 1958 Arthur Kornberg +4 more
openaire +2 more sources
8-Hydroxy-2-Deoxyguanosine Levels and Cardiovascular Disease: A Systematic Review and Meta-Analysis of the Literature [PDF]
, 2016 Significance: 8-Hydroxy-2-deoxyguanosine (8-OHdG) is generated after the repair of ROS-mediated DNA damages and, thus, is one of the most widely recognized biomarkers of oxidative damage of DNA because guanosine is the most oxidized among the DNA ...
Cavalca, Viviana +6 more
core +1 more source
8-Oxo-2’-deoxyguanosine – biomarker of the oxidative stress
Тонкие химические технологии, 2014 Free radical mechanism of a cell damage is one of the universal non-specific pathogenic pathways in a cause of many diseases, including cancer, neurodegenerative diseases, atherosclerosis and aging.
T. S. Nevredimova +4 more
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