Results 81 to 90 of about 192,494 (228)

Effects of photobiomodulation therapy on pulmonary inflammation in chronic asthma: Dosimetric study in an experimental model

Photochemistry and Photobiology, EarlyView.
Photobiomodulation therapy (PBMT) was evaluated across a radiant energy range (1–7.5 J) in a murine model of chronic ovalbumin‐induced asthma to identify the optimal therapeutic dose. PBMT attenuated airway inflammation and remodelling, suppressed Th2 cytokines, and enhanced regulatory immune responses, highlighting a dose‐dependent immunomodulatory ...
Tawany Gonçalves Santos, Cintia Estefano Alves, Aurileia Aparecida de Brito, Bibiana Padilha de Menezes da Silva, Cinthya Cosme Gutierrez Duran, Stella Zamuner, Rodrigo Labat, José Antonio Silva Junior, Maria Cristina Chavantes, Flavio Aimbire, Renata Kelly da Palma, Ana Paula Ligeiro de Oliveira   +11 more
wiley   +1 more source

Probing the Catalytic Mechanism of Bovine Pancreatic Deoxyribonuclease I by Chemical Rescue

, 2008
Previous structural and mutational studies of bovine pancreatic deoxyribonuclease I (bpDNasc I) have demonstrated that the active site His 134 and His252 played critical roles in catalysis. In our present study, mutations of these two His residues to Gin,
Chen, Wei-Jung; Lai, Pei-Jun; Lai, Yu-Shen; Huang, Po-Tsang; Lin, Chai-Ching; Liao, Ta-Hsiu, 陳威戎;黃柏蒼;廖大修   +1 more
core  

Construction and Characterization of a Bifunctional Enzyme with Deoxyribonuclease I and Thioredoxin-Like Activities

, 2008
One large essential (C173-C209) and one small nonessential ( C101-CI04) disulfide loops occur in bovine pancreatic deoxyribonuclease I (bpDNase I) . In our recent study, the reduced nonessential disulfide (-CESC-), which is structurally homologous to the
Chen, Wei-Jung; Lo, Ting; Lai, Yu-Shen; Huang, Po-Tsang; Lin, Chai-Ching; Liao, Ta-Hsiu, 陳威戎;廖大修   +1 more
core  

Effect of deoxyribonuclease I on the electrophoretic profile of the long chain DNA fibers.

, 2013
Effect of deoxyribonuclease I on the electrophoretic profile of the long chain DNA fibers.
Joji Yoshida (313868), Kiyoshi Takamatsu (313870), Satoru Kaneko (313867), Hiromichi Ishikawa (313869)   +3 more
core   +1 more source

FGFR Inhibitor AZD4547 Disrupts Inflammatory CAF Crosstalk With Cancer Cells and Macrophages and Attenuates Metastasis in Pancreatic Cancer

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
This study demonstrates that FGFR‐targeted inhibition by AZD4547 in inflammatory cancer‐associated fibroblasts (iCAFs) intervenes into the tumor–stroma crosstalk. AZD4547 blocks IL‐1α–induced differentiation of pancreatic stellate cells into iCAFs, impairing iCAF‐driven tumor cell differentiation, migration, and M2 macrophage polarization. Consequently,
Ahmed M. R. H. Mostafa, Ahmed G. Hemdan, Franck Assayag, Jai Prakash   +3 more
wiley   +1 more source

A Deoxyribonuclease from Rabbit Leucocytes.

Experimental Biology and Medicine, 1966
SummaryRabbit leucocytes from sterile peritoneal exudates contain a potent acid DNase. By differential sonification and cellulose column chromatography this enzyme has been purified 140-fold. The properties of the enzyme are discussed and the similarity to and differences from previously described DNases are mentioned.
D L, Bornstein, A N, Weinberg, M N, Swartz   +2 more
openaire   +2 more sources

The functions of Deoxyribonuclease II in immunity and development

, 2008
International audienceApoptosis, which is usually accompanied by DNA degradation, is important not only for the homeostasis of metazoans but also for mammalian development. If DNA is not properly degraded in these processes, it can cause diverse diseases,
Yan-ling Yu, Pascal Boireau, Wang, Wei Fang, Ma-feng Liu, Chen, Qi Jun, Ming-yuan Liu, Qi-jun Chen, Xue-lin Wang, Liu, Ma Feng, Yu, Yan Ling, Boireau, Pascal, Wu, Xiu Ping, Wang, Xue Lin, Liu, Ming Yuan, Wei-fang Wang, Xiu-ping Wu   +15 more
core   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, Volume 13, Issue 37, 3 July 2026.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

An automated method for the determination of deoxyribonuclease activity as exemplified by fractionation of the components of the medicament Varidase®

, 1993
The activity of most deoxyribonuclease enzymes can be monitored by measuring the change in absorbance at 260 nm which accompanies the breakdown of the double-stranded structure of native DNA. An automated method for determining deoxyribonuclease activity,
Ramsay, M.P., Carpenter, B.G., Hill, S.S., Locke, I.C.   +3 more
core  

Mining Clinical Case Reports to Identify New Lines of Investigation in Alzheimer’s Disease: The Curious Case of DNase I

Journal of Alzheimer's Disease Reports, 2019
Mining the case report literature identified an intriguing, yet neglected finding: Deoxyribonuclease I (DNase I) as a possible treatment for Alzheimer’s disease.
Neil R. Smalheiser
doaj   +1 more source