Results 101 to 110 of about 2,522 (141)
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Mammalian deoxyribonucleoside kinases
Pharmacology & Therapeutics, 1995The mammalian deoxyribonucleoside kinases are deoxycytidine kinase, thymidine kinase 1 and 2 and deoxyguanosine kinase. These enzymes phosphorylate deoxyribonucleosides and thereby provide an alternative to de novo synthesis of DNA precursors. Their activities are essential for the activation of several chemotherapeutically important nucleoside ...
E S, Arnér, S, Eriksson
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Biochemical Pharmacology, 1975
Abstract The effects of deoxyribonucleosides on the intracellular levels of deoxyribonucleoside triphosphates (dNTP) and on the rate of labelled thymidine incorporated into DNA of human phytohaemag-glutinin-stimulated lymphocytes have been studied. Thymidine (10−2–10−6M) expanded the dTTP and reduced dATP and dCTP levels.
M H, Tattersall +2 more
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Abstract The effects of deoxyribonucleosides on the intracellular levels of deoxyribonucleoside triphosphates (dNTP) and on the rate of labelled thymidine incorporated into DNA of human phytohaemag-glutinin-stimulated lymphocytes have been studied. Thymidine (10−2–10−6M) expanded the dTTP and reduced dATP and dCTP levels.
M H, Tattersall +2 more
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Fluorescence of hydrocarbon-deoxyribonucleoside adducts
Chemico-Biological Interactions, 1979In comparison with the fluorescence emission spectra of 7-methylbenz[a]-anthracene-nucleoside adducts, the fluorescence emission spectra of hydrocarbon-deoxyribonucleoside adducts containing a methyl substituent in the "bay region" lack spectral resolution at room temperature and appear at substantially longer wavelength.
R C, Moschel, W R, Hudgins, A, Dipple
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Plants Salvage Deoxyribonucleosides in Mitochondria
Nucleosides, Nucleotides and Nucleic Acids, 2014Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides into the corresponding 5'-monophosphate deoxyribonucleosides to supply the cell with nucleic acid precursors. In mitochondrial fractions of the model plant Arabidopsis thaliana, we detected deoxyadenosine and thymidine kinase activities, while the cytosol fraction contained six-fold lower ...
Anders R, Clausen +3 more
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Journal of Molecular Biology, 2007
The salvage of deoxyribonucleosides in the social amoeba Dictyostelium discoideum, which has an extremely A+T-rich genome, was investigated. All native deoxyribonucleosides were phosphorylated by D. discoideum cell extracts and we subcloned three deoxyribonucleoside kinase (dNK) encoding genes. D.
Michael Paolo Bastner, Sandrini +3 more
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The salvage of deoxyribonucleosides in the social amoeba Dictyostelium discoideum, which has an extremely A+T-rich genome, was investigated. All native deoxyribonucleosides were phosphorylated by D. discoideum cell extracts and we subcloned three deoxyribonucleoside kinase (dNK) encoding genes. D.
Michael Paolo Bastner, Sandrini +3 more
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Biochemical Pharmacology, 1987
Inhibition of cell growth and DNA synthesis by hydroxyurea is thought to occur via an effect on the enzyme ribonucleotide reductase leading to a block of deoxyribonucleotide synthesis. Earlier attempts to bypass such a block by delivering deoxyribonucleosides to the medium of cultured cells have given equivocal results.
J, Lagergren, P, Reichard
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Inhibition of cell growth and DNA synthesis by hydroxyurea is thought to occur via an effect on the enzyme ribonucleotide reductase leading to a block of deoxyribonucleotide synthesis. Earlier attempts to bypass such a block by delivering deoxyribonucleosides to the medium of cultured cells have given equivocal results.
J, Lagergren, P, Reichard
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Drosophila melanogaster deoxyribonucleoside kinase activates gemcitabine
Biochemical and Biophysical Research Communications, 2009Drosophila melanogaster multisubstrate deoxyribonucleoside kinase (Dm-dNK) can additionally sensitize human cancer cell lines towards the anti-cancer drug gemcitabine. We show that this property is based on the Dm-dNK ability to efficiently phosphorylate gemcitabine.
Wolfgang, Knecht +6 more
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Reduction of Ribonucleosides to 2′‐Deoxyribonucleosides
Current Protocols in Nucleic Acid Chemistry, 2005AbstractRibonucleosides are converted into 2′‐deoxyribonucleosides in good yields by a four‐step procedure. Selective protection of the 3′‐ and 5′‐hydroxyl groups with 1,3‐dichloro‐1,1,3,3‐tetraisopropyl‐1,3‐disiloxane is followed by functionalization of the 2′‐hydroxyl group with phenoxythiocarbonyl chloride.
Morris J, Robins, Stanislaw F, Wnuk
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Deoxyribonucleoside triphosphate pools and adenosine toxicity
Biochemical Pharmacology, 1977Abstract The toxic effect of adenosine on the metabolism of malignant lymphoid cells has been studied in relation to the activity of intracellular adenosine deaminase. Exposure in vitro of L1210 and L5178Y cells for 48 hr to adenosine demonstrated that concentrations above 10 −5 M inhibited cell division, the toxic effect being inversely ...
J F, Smyth, K R, Harrap
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