Results 111 to 120 of about 2,522 (141)

Halogenated Pyrimidine Deoxyribonucleosides

1975
The halogenated uracil derivatives are not only powerful tools for elucidation of many intricate biochemical events of importance to molecular biology but also they have valuable clinical utility. This review is directed to an understanding of why these compounds function as they do, and in addition to indicate the many uses that they have.
William H. Prusoff, Barry Goz
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Stereoisomeric Selectivity of Human Deoxyribonucleoside Kinases

Biochemistry, 1999
Deoxynucleoside kinases catalyze the 5'-phosphorylation of 2'-deoxyribonucleosides with nucleoside triphosphates as phosphate donors. One of the cellular kinases, deoxycytidine kinase (dCK), has been shown to phosphorylate several L-nucleosides that are efficient antiviral agents.
J, Wang, D, Choudhury, J, Chattopadhyaya, S, Eriksson   +3 more
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Chemical reactivity analysis of deoxyribonucleosides and deoxyribonucleoside analogues (NRTIs): a first-principles density functional approach

Journal of Molecular Modeling, 2012
The structures, energetics, as well as several important chemical parameters, of antiretroviral drugs - nucleoside reverse transcriptase inhibitors (NRTIs) - and natural deoxyribonucleosides in both neutral, and positively and negatively charged states, are investigated.
Vipin, Kumar, Shyam, Kishor, Lavanya M, Ramaniah   +2 more
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Syntheses of Aliphatic Polycarbonates from 2′-Deoxyribonucleosides

Biomacromolecules, 2011
Poly(2'-deoxyadenosine) and poly(thymidine) constructed of carbonate linkages were synthesized by polycondensation between silyl ether and carbonylimidazolide at the 3'- and 5'-positions of the 2'-deoxyribonucleoside monomers. The N-benzoyl-2'-deoxyadenosine monomer afforded the corresponding polycarbonate together with the cyclic oligomers.
Masato, Suzuki, Toyokazu, Sekido, Shin-ichi, Matsuoka, Koji, Takagi   +3 more
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Deoxyribonucleoside Kinases in Mitochondrial DNA Depletion

Nucleosides, Nucleotides and Nucleic Acids, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
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Substituent Influence on the Reaction Rate of Deoxyribonucleoside Phosphoramidites with Deoxyribonucleosides Catalysed by Tetrazole

Nucleosides and Nucleotides, 1987
Abstract The rates of formation of some dinucleoside phosphites 3 from different deoxyribonuclroside phosphoramidites 1 and a common nucleoside 2a (Scheme) have been compared.
DAHL, BH, Nielsen, John, DAHL, O
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Identification of purine deoxyribonucleoside kinases from human leukemia cells: substrate activation by purine and pyrimidine deoxyribonucleosides

Biochemistry, 1987
Cell extracts from human leukemic T lymphoblasts and myeloblasts were chromatographed on DEAE-cellulose columns to separate purine deoxyribonucleoside, deoxyadenosine (dAdo) and deoxyguanosine (dGuo), phosphorylating activities. Three distinct purine deoxyribonucleoside kinases, a deoxycytidine (dCyd) kinase, an adenosine (Ado) kinase, and a ...
J C, Sarup, A, Fridland
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Detection of Deoxyribonucleosides on Paper Chromatograms

Nature, 1951
THE paper chromatography of deoxyribonucleosides has been described by several workers1–5. The compounds can be located on the chromatogram by examination under ultra-violet light1,6,7, by a microbiological method2,3,5 or by means of the Feulgen or Dische reactions4.
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Purine Deoxyribonucleoside Induced Hepatotoxicity in the Mouse

1984
Although treatment of mice with the adenosine deaminase (ADA) inhibitor 2f-deoxycoformycin (dCf) in combination with 2′-deoxyadenosine (AdR) resulted in bone marrow toxicity, death was attributable to acute hepatic dysfunction.1 The toxic effects of AdR in ADA inhibited cells have been attributed to several different processes including inhibition of ...
J, Renshaw, R M, Paine, G A, Taylor, K R, Harrap   +3 more
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Human Deoxycytidine Kinase as a Deoxyribonucleoside Phosphorylase

Journal of Molecular Biology, 2004
Human deoxycytidine kinase (dCK) is a key enzyme in the 5'-phosphorylation of purine and pyrimidine deoxynucleosides with deoxycytidine as the most efficient substrate. The ability of dCK to degrade 2'-deoxyribonucleosides to free nucleobases and 2-deoxy-alpha-d-ribofuranose-1-phosphate was demonstrated by 1H-31P correlation spectroscopy and by isotope
Elena, Usova, Tatiana, Maltseva, András, Földesi, Jyoti, Chattopadhayaya, Staffan, Eriksson   +4 more
openaire   +2 more sources