Results 121 to 130 of about 2,522 (141)

THE SUGAR COMPONENT OF DEOXYRIBONUCLEOSIDES

Canadian Journal of Chemistry, 1956
From highly polymerized deoxyribonucleate the nucleosides have been isolated by an improved method. The sugar obtained on hydrolysis of the individual nucleosides has been shown to be D-2-deoxyribose in each case.
I. G. Walker, G. C. Butler
openaire   +1 more source

Structural Basis for Feedback Inhibition of the Deoxyribonucleoside Salvage Pathway:  Studies of the Drosophila Deoxyribonucleoside Kinase

Biochemistry, 2003
Deoxyribonucleoside kinases are feedback inhibited by the final products of the salvage pathway, the deoxyribonucleoside triphosphates. In the present study, the mechanism of feedback inhibition is presented based on the crystal structure of a complex between the fruit fly deoxyribonucleoside kinase and its feedback inhibitor deoxythymidine ...
Mikkelsen, Nils Egil, Johansson, Kenth, Karlsson, Andreas, Knecht, Wolfgang, Andersen, Gorm, Piskur, Jure, Munch-Petersen, Birgitte, Eklund, Hans   +7 more
openaire   +3 more sources

Deoxyribonucleoside interaction as measured by rotary dispersion

Biochimica et Biophysica Acta, 1957
Abstract The rotary dispersion of individual nucleosides and mixtures of nucleosides has been determined. Interactions have been found as indicated by the marked departure from the simple additivity of rotary dispersions in paired mixtures of nucleosides normally found in DNA.
B H, LEVEDAHL, T W, JAMES
openaire   +2 more sources

Structure and function of cellular deoxyribonucleoside kinases

Cellular and Molecular Life Sciences CMLS, 2002
Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides, a crucial reaction in biosynthesis of DNA precursors through the salvage pathway. Their medical interest stems from their activation of a number of anticancer and antiviral drugs such as 2-chloro-2'-deoxyadenosine, azidothymidine and acyclovir.
S, Eriksson, B, Munch-Petersen, K, Johansson, H, Eklund   +3 more
openaire   +2 more sources

Synthesis of 1, 7-Dideazapurine Ribonucleosides and Deoxyribonucleosides

Nucleosides and Nucleotides, 1993
Abstract The synthesis of hydroxylamino derivatives of 1,7-dideazaadenosine and of 1,7-dideaza-2′-deoxyadenosine, starting from 4-nitro-1H-pyrrolo[2,3-b]pyridine (1), is described. None of the synthesized compounds are substrates of adenosine deaminase and two of them (3 and 18) are weak inhibitors.
G. Cristalli, S. Vittori, A. Eleuteri, R. Volpini, D. Cola, CAMAIONI, Emidio, P. V. Gariboldi, G. Lupidi   +7 more
openaire   +3 more sources

Deoxyribonucleoside Cyclic 3',5'-Phosphorofluondates

Phosphorus, Sulfur, and Silicon and the Related Elements, 1996
Abstract The synthesis of nucleoside cyclic 3′,5′-phosphorofluoridates, so far not described compounds in the chemical literature, have been performed. As a key substrate we used 2′-deoxyribonucleoside cyclic 3′,5′-phosphorothioates (1) which have been obtained in this Laboratory several years ago ...
openaire   +1 more source

Purine Ribonucleoside and Deoxyribonucleoside Metabolism in Thymocytes

1980
The human deficiencies of adenosine deaminase and purine nucleoside phosphorylase activities are associated with an accumulation of the purine deoxyribonucleoside triphosphates, dATP (1–4) and dGTP (4) respectively. In the absence of adenosine deaminase or purine nucleoside phosphorylase activities, deoxyadenosine or deoxyguanosine are presumed to be ...
F F, Snyder, T, Lukey
openaire   +2 more sources

A convenient synthesis of 5′-deoxyribonucleosides

Carbohydrate Research, 1977
Abstract A facile, two-step synthesis has been devised for the chemical preparation of 5′-deoxyribonucleosides from the parent nucleosides via the 5′-chloro-5′-deoxy-nucleosides. Treatment of 5′-chloro-5′-deoxynucleosides with tributyltin hydride and α,α′-azobis(isobutyronitrile) in dry tetrahydrofuran yields the corresponding 5′-deoxy-nucleosides ...
Yueh Wang, Harry P.C. Hogenkamp, Robert A. Long, Ganapathi R. Revankar, Roland K. Robins   +4 more
openaire   +1 more source

Stereocontrolled synthesis of α-2′-deoxyribonucleosides

Tetrahedron Letters, 1997
Abstract A stereocontrolled synthesis of α-2′-deoxynucleosides has been achieved. Our synthetic strategy involves the use of a benzoyl group at the 2-position of arabinose as a directing group for Vorbruggen glycosylation and a deoxygenation precursor.
Zhiwei Wang, Carmelo J Rizzo
openaire   +1 more source

Oxidation of 4′-deoxyribonucleoside radicals to 4′-deoxyribonucleoside cations. A model for the function of bleomycin

Tetrahedron Letters, 1998
Abstract Selective generation of the 4′-deoxyribonucleoside radical 8 in the presence of Mn(OAc) 3 gave acetal 9 in 91% yield. This reaction models the function of the antibiotic bleomycin under diminished O 2 concentrations. In the presence of O 2 a peroxy radical is formed that leads to completely different products.
Xenia Beyrich-Graf, Stephan N. Müller, Bernd Giese   +2 more
openaire   +1 more source