Results 11 to 20 of about 2,522 (141)
Replicative bypass studies of l-deoxyribonucleosides in Vitro and in E. coli cell
Scientific Reports, 2022 l-nucleosides were the most important antiviral lead compounds because they can inhibit viral DNA polymerase and DNA synthesis of many viruses, whereas they may lead to mutations in DNA replication and cause genomic instability.
Yuhe Kan +6 more
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Deoxyribonucleoside-requiring Mutants of Bacillus subtilis [PDF]
Journal of General Microbiology, 1978 A number of deoxyribonucleoside-requiring mutants (dns) of Bacillus subtilis were isolated and their growth characteristics and ribonucleotide reductase activities were compared with those of the wild type and of a dna mutant (tsA13). Both tsA13 and dns mutants required the presence of a mixture of deoxyribonucleosides for growth at 45 degrees C but ...
B K, Rima, I, Takahashi
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Phospholipase D1 Couples CD4+ T Cell Activation to c-Myc-Dependent Deoxyribonucleotide Pool Expansion and HIV-1 Replication. [PDF]
PLoS Pathogens, 2015 Quiescent CD4+ T cells restrict human immunodeficiency virus type 1 (HIV-1) infection at early steps of virus replication. Low levels of both deoxyribonucleotide triphosphates (dNTPs) and the biosynthetic enzymes required for their de novo synthesis ...
Harry E Taylor +7 more
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Biomimetic Ketone Reduction by Disulfide Radical Anion
Molecules, 2021 The conversion of ribonucleosides to 2′-deoxyribonucleosides is catalyzed by ribonucleoside reductase enzymes in nature. One of the key steps in this complex radical mechanism is the reduction of the 3′-ketodeoxynucleotide by a pair of cysteine residues,
Sebastian Barata-Vallejo +5 more
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Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance. [PDF]
PLoS ONE, 2014 Efficient and adequate generation of deoxyribonucleotides is critical to successful DNA repair. We show that ataxia telangiectasia mutated (ATM) integrates the DNA damage response with DNA metabolism by regulating the salvage of deoxyribonucleosides ...
Yuri L Bunimovich +7 more
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A multisubstrate deoxyribonucleoside kinase from plants [PDF]
Nucleic Acids Symposium Series, 2008 Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants.
Anders Ranegaard, Clausen +6 more
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Beilstein Journal of Organic Chemistry, 2020 For the first time, a metal-mediated base pair has been used to modulate the affinity of an aptamer towards its target. In particular, two artificial imidazole 2’-deoxyribonucleosides (Im) were incorporated into various positions of an established ATP ...
Marius H. Heddinga, Jens Müller
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Incorporation of Deoxyribonucleosides into DNA of Coryneform Bacteria and the Relevance of Deoxyribonucleoside Kinases [PDF]
European Journal of Biochemistry, 1982 In order to obtain basic knowledge of the salvage pathways for DNA synthesis, the ability of Brevibacterium ammoniagenes ATCC 6872 and Micrococcus luteus ATCC 15932 for incorporation of nucleobases and nucleo–sides was investigated. Only adenine and uracil are incorporated by B. ammoniagenes, whereas M.
G, Auling, H, Prelle, H, Diekmann
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Molecules, 2022 Camellia vietnamensis Huang is an important woody oil crop in China, which has attracted much attention because of its abundant nutritional components and pharmaceutical value.
Heqin Yan +4 more
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Deoxyribonucleoside triphosphate accumulation by leukemic cells [PDF]
Blood, 1983 The toxicity of the deoxyribonucleosides, 2′-deoxyadenosine, 2′- deoxyguanosine, and thymidine, for human T lymphoblasts is mediated by the accumulation of the corresponding deoxyribonucleoside triphosphate (dATP, dGTP, or dTTP, respectively). We have examined whether leukemic cells of non-T-cell origin are capable of accumulating deoxyribonucleotides ...
B S, Mitchell, N L, Edwards, C A, Koller
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