Results 51 to 60 of about 2,522 (141)

DNA methyltransferase inhibitors in hematological malignancies and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.
Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger, Guillermo Garcia‐Manero, Robert Zeiser, Michael Lübbert   +3 more
wiley   +1 more source

Biocatalytic Construction of a Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Nucleoside Probe: Synthesis and Evaluation of 5‐Methyl‐5,6‐Dihydrothymidine

Advanced Synthesis &Catalysis, Volume 368, Issue 1, January 2026.
Al‐Hilfi et al. present a biocatalytic strategy for synthesizing 5‐methyl‐5,6‐dihydrothymidine (5‐MDHT), a sensitive MRI contrast agent. The study demonstrates that recombinant enzyme catalysis offers an efficient, sustainable, and eco‐friendly alternative to traditional chemical synthesis for producing clinically relevant imaging probes.
Aimen Al‐Hilfi, E. Alejandro Castellanos Franco, Connor J. Grady, Zinia Mohanta, Michael T. McMahon, Milana Bazayeva, Zhen Li, Kenneth M. Merz Jr., Assaf A. Gilad   +8 more
wiley   +1 more source

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source

New Benzimidazole 3′-Deoxynucleosides: Synthesis and Antiherpes Virus Properties

Biomolecules
A series of new 3′-deoxyribosides of substituted benzimidazoles was obtained by the chemo-enzymatic method using genetically engineered E. coli purine nucleoside phosphorylase (PNP).
Aleksandra O. Arnautova, Irina A. Aleksakhina, Ekaterina A. Zorina, Maria Ya. Berzina, Ilya V. Fateev, Barbara Z. Eletskaya, Konstantin V. Antonov, Olga S. Smirnova, Alexander S. Paramonov, Alexey L. Kayushin, Valeria L. Andronova, Georgii A. Galegov, Maria A. Kostromina, Evgeny A. Zayats, Inna L. Karpenko, Svetlana K. Kotovskaya, Valery N. Charushin, Roman S. Esipov, Anatoly I. Miroshnikov, Irina D. Konstantinova   +19 more
doaj   +1 more source

Reinvestigation of deoxyribonucleoside phosphorothioites: synthesis and properties of deoxyribonudeoside-3′ dimethyl phosphites

Nucleic Acids Research, 1989
Further investigation of the synthesis of deoxyribonucleoside-3' (t-butyl) O-(2-cyanoethyl) phosphorothioites as monomer building units for the phosphorothioite approach has led us to conclude that internucleotidic bond formation proceeded via bis(deoxyribonucleoside-3') (2-cyanoethyl) phosphite intermediates, which proved to be activated by iodine ...
H, Nagai, T, Fujiwara, M, Fujii, M, Sekine, T, Hata   +4 more
openaire   +3 more sources

Simultaneous RNA and DNA Adductomics Using Single Data-Independent Acquisition Mass Spectrometry Analysis. [PDF]

Chem Res Toxicol, 2023
Martella G, Motwani NH, Khan Z, Sousa PFM, Gorokhova E, Motwani HV.   +5 more
europepmc   +1 more source

Metabolic isotopic labeling of (deoxy)ribose enables dual neutral loss scanning for profiling nucleic acid modifications. [PDF]

Nucleic Acids Res
Rong SQ, Jin ZH, Yin DR, Yao J, Xu GL, Zhu P, Gao H, Zhou D.   +7 more
europepmc   +1 more source

Role of gut microbiota and immune response in breast cancer progression. [PDF]

Biomol Biomed
Zhang X, Ma N, Jin C, Cao X.
europepmc   +1 more source

Pioneering contribution of Professor Bruce Ames to early development in biochemical aspects of oxidatively generated damage to DNA. [PDF]

Front Mol Biosci
Cadet J, Wagner JR.
europepmc   +1 more source

Phosphorylation of nucleosides by P-N bond species generated from prebiotic reduced phosphorus sources. [PDF]

Commun Chem
Gull M, Cruz HA, Krishnamurthy R, Pasek MA.   +3 more
europepmc   +1 more source