Results 11 to 20 of about 65 (48)

Near‐infrared light‐activated aptamer‐based nanoprobe for spatiotemporally resolved detection of L‐lactate in colorectal cancer

BMEMat, EarlyView.
A near‐infrared (NIR) light‐activated “lock‐key” nanodevice is reported for spatiotemporally resolved detection of intratumoral L‐lactate. The system stays silent until deep‐penetrating NIR light remotely unlocks its function, allowing for precise sensing within tumors.
Siyu Pan, Xuanyi Lu, Wenjie Yang, Yunhui Peng, Lingfu Deng, Shuai Zha, Xueyang Fang, Guochen Bao, Lijun Jiang   +8 more
wiley   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Cerebral oxygen extraction across different exercise intensities: Role of arterial PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_2}}}$

Experimental Physiology, EarlyView.
Abstract Stability in cerebral oxygen extraction fraction (OEF) is typically determined by alterations in cerebral blood flow (CBF). At rest, arterial partial pressure of carbon dioxide (PaCO2${P_{{\mathrm{aC}}{{\mathrm{O}}_2}}}$) and OEF exhibit a strong inverse relationship owing to the powerful influence of PaCO2${P_{{\mathrm{aC}}{{\mathrm{O}}_2}}}$
L. Madden Brewster, Travis Dylan Gibbons, Hannah Grace Caldwell, Connor A. Howe, Jennifer S. Duffy, Andrew R. Steele, Justin A. Monteleone, Jay M. J. R. Carr, Jodie Lauren Koep, Tenasia D. R. Monaghan, David B. MacLeod, Philip N. Ainslie   +11 more
wiley   +1 more source

Advances in Chitosan Nanoparticles: A Comprehensive Review of Properties, Synthesis, Characterization, Multidisciplinary Applications, and Future Perspectives

Journal of Applied Polymer Science, Volume 143, Issue 33, September 5, 2026.
This review highlights the synthesis of chitosan nanoparticles from natural sources, the thorough characterization of them, and use of microscopic and spectroscopic methods. It emphasizes that it has some indispensable properties such as being non‐toxic, antimicrobial, and capable of controlled drug release.
Mariam Sohail Mansoor, Nayab Raza, Furqana Bibi, Madiha Mumtaz, Asif Abbas, Farasat Haider, Basit Ali   +6 more
wiley   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, Volume 13, Issue 43, 3 August 2026.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

HCTR+: An Optimally Secure TBC-Based Accordion Mode

IACR Transactions on Symmetric Cryptology
The design of tweakable wide-block ciphers has advanced significantly over the past two decades. This evolution began with the wide-block cipher by Naor and Reingold.
Nilanjan Datta, Avijit Dutta, Shibam Ghosh, Eik List, Hrithik Nandi   +4 more
doaj   +1 more source

Dietary nutgrass (Cyperus rotundus) extract–loaded chitosan nanoparticles: Enhance growth performance, boost immune responses, improve antioxidant capacity, and physiological performance in white leg shrimp (Litopenaeus vannamei)

Journal of the World Aquaculture Society, Volume 57, Issue 4, August 2026.
Abstract Aquaculture has increasingly turned toward plant extracts' usage as functional additives, owing to their rich content of bioactive compounds that enhance growth performance, boost immune responses, and improve antioxidant capacity in cultured species.
Nader N. Hassona, Nauman Khan, Maryam Alenize, Ahmed Tayel, Salma Elhussein, Jia Longwu, Huici Yang, Yun Li, Nusrat Liaqat, Xilin Dai   +9 more
wiley   +1 more source

Plantar Foot Microvascular Reactivity and Oxygenation in Type 2 Diabetes and Peripheral Artery Disease: An Exploratory Study

Microcirculation, Volume 33, Issue 6, August 2026.
ABSTRACT Objective Microvascular dysfunction contributes to foot complications in type 2 diabetes (T2D) and peripheral artery disease (PAD), yet has been characterized primarily in non‐plantar regions. We evaluated microvascular reactivity and oxygenation at ulcer‐prone plantar sites and responses to combined heat therapy and intermittent pneumatic ...
Josi Gallo, Allison Miller, Emily Chan, Grace Chen, Luke Benner, Erik Sillaste, Brhandom Brisueno Lopez, Carolyn Bakx, Bohyun Ro, Juan Orsi, Lara Soares de Araujo, Ernesto Ramirez, Eloisa Herrera Ospina, Qifan Song, Daniel M. Hirai, Igor A. Fernandes, Bruno T. Roseguini   +16 more
wiley   +1 more source

Strain‐Specific Biotransformation of Grape Marc by Lactic Acid Bacteria: Genomic Validation and Gut Microbiota Modulation

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Grape marc (GM) is a polyphenol‐rich winery byproduct that remains underutilized due to its complex fiber matrix, which limits the bioaccessibility of bound phenolics. While lactic acid fermentation (LAF) can enhance the release of these compounds, the strain‐specific metabolic fate of GM phenolics during digestion and colonic fermentation ...
Ziyao Liu, Hanjing Wu, Brendan Holland, Colin J. Barrow, Hafiz A. R. Suleria   +4 more
wiley   +1 more source

Safety evaluation of a food enzyme containing endo‐polygalacturonase and pectin lyase activities from the non‐genetically modified Aspergillus luchuensis strain NZYM‐XA

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The food enzyme containing endo‐polygalacturonase (1,4‐α‐d‐galacturonan glycanohydrolase; EC 3.2.1.15) and pectin lyase (1,4‐6‐O‐methyl‐α‐d‐galacturonan lyase; EC 4.2.2.10) activities is produced with the non‐genetically modified microorganism Aspergillus luchuensis strain NZYM‐XA by Novozymes A/S.
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Pier Sandro Cocconcelli, Cristina Andreoli, Andrea Terron, Andrey Yurkov, Jaime Aguilera, Magdalena Andryszkiewicz, Ana Criado, Francesco Pesce, Yi Liu   +21 more
wiley   +1 more source