Results 61 to 70 of about 4,975,318 (340)

Age-related changes of dopamine D1 and D2 receptors expression in parvalbumin-positive cells of the orbitofrontal and prelimbic cortices of mice

open access: yesFrontiers in Neuroscience
Dopamine (DA) plays a pivotal role in reward processing, cognitive functions, and emotional regulation. The prefrontal cortex (PFC) is a critical brain region for these processes.
Jihui Dong   +9 more
doaj   +1 more source

Psychometric properties of the Turkish version of Drug Use Disorders Identification Test–Extended (Turkish DUDIT-E) in substance-dependent adults under probation

open access: yesPsychiatry and Clinical Psychopharmacology, 2017
Objective: Motivation is a widely used concept in substance use treatment, which is related to the change during treatment. The Drug Use Disorders Identification Test–Extended (DUDIT-E) is one of the instruments to measure motivation.
Cuneyt Evren   +4 more
doaj   +1 more source

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu   +20 more
wiley   +1 more source

A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou   +10 more
wiley   +1 more source

A review of systematic reviews for evidence on use of mobile applications for mental disorders, including substance use disorders, in low and middle-income countries

open access: yesDigital Health
Background and objectives There is an increased burden of mental disorders, including substance use disorders (MSUD) in low- and middle-income countries (LMICs). Digital technology offers a viable avenue to scale up the services for MSUD in such settings.
Riya Kaur Bhatia   +12 more
doaj   +1 more source

Pi4KIIα Regulates Unconditioned Stimulus-Retrieval-Induced Fear Memory Reconsolidation through Endosomal Trafficking of AMPA Receptors

open access: yesiScience, 2020
Summary: Targeting memory reconsolidation is an effective intervention for treating posttraumatic stress disorder (PTSD). Disrupting unconditioned stimulus (US)-retrieval-induced fear memory reconsolidation has become an effective therapeutic approach to
Hongling Guo   +12 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Trivializing dependence [PDF]

open access: yesBritish Journal of Addiction, 1990
AbstractThere are a number of repetitive behaviors which have in common what appears to be a decrease in an individual's capacity to choose to discontinue them. The taxonomy we select to categorize these behaviors depends on our objectives. Broad definition which label as ‘addictions’ both repetitive use of drugs and repetitive behaviors not related to
openaire   +2 more sources

A Dependent Dependency Calculus

open access: yes, 2022
AbstractOver twenty years ago, Abadi et al. established the Dependency Core Calculus (DCC) as a general purpose framework for analyzing dependency in typed programming languages. Since then, dependency analysis has shown many practical benefits to language design: its results can help users and compilers enforce security constraints, eliminate dead ...
Pritam Choudhury   +2 more
openaire   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

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