Results 151 to 160 of about 5,883,864 (257)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Trust in Generative AI for Health Information Consumption and the Effect of Learned Dependency: Randomized Controlled Experimental Study. [PDF]
J Med Internet ResAhmed A +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Propagation Mechanisms of Security Risks in Public Data Circulation via Inter-Risk Dependencies: A DSM-Based Network Analysis. [PDF]
Risk AnalWang N, Li Y, Mikkonen T, Li W, Cong F.
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
A dual-moderation model of physical activity and gender in the relationship between experiential avoidance and short video dependency. [PDF]
Front PsycholLei J, Tan X.
europepmc +1 more source
Dependency Theory and its Influence on Chinese Higher Education Research
, 2008 依附理论是20世纪50年代兴起的诠释拉丁美洲国家不发达原因的理论总称。随着"依附"外延的扩大,依附理论被引入到中国高等教育研究并产生了积极的影响,如增强了对文化殖民的警觉意识、扩大了研究对象和范围等。但它也产生了消极的影响,如将依附理论简单套用、将少数研究依附问题泛化、将借鉴等同于依附、将中国高等教育研究误认为是依附发展等。因而审视依附理论的发展,厘清依附理论在我国高等教育研究中的应用及其产生的影响具有重要的理论意义和现实意义。Dependency Theory,developed in the ...
吴薇
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source