Results 31 to 40 of about 4,508,134 (250)

Statistical inference for Nadarajah-Haghighi distribution under unified hybrid censored competing risks data

Heliyon
Nadarajah and Haghighi distribution (NHD) inferences problem has been discussed under unified hybrid censoring scheme (UHCS) in the existence of competing risks model.
Tahani A. Abushal
doaj   +1 more source

ESHOL study reanalysis: All-cause mortality considered by competing risks and time-dependent covariates for renal transplantation

Nefrología (English Edition), 2016
Background: The ESHOL study showed that post-dilution online hemodiafiltration (OL-HDF) reduces all-cause mortality versus hemodialysis. However, during the observation period, 355 patients prematurely completed the study and, according to the study ...
Francisco Maduell, Francesc Moreso, Josep Mora-Macià, Mercedes Pons, Rosa Ramos, Jordi Carreras, Jordi Soler, Ferrán Torres   +7 more
doaj   +1 more source

A copula model for dependent competing risks [PDF]

, 2010
Many popular estimators for duration models require independent competing risks or independent censoring. In contrast, copula-based estimators are also consistent in the presence of dependent competing risks.
Simon M. S. Lo, Ralf A. Wilke
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A copula model for dependent competing risks [PDF]

"Many popular estimators for duration models require independent competing risks or independent censoring. In contrast, copula based estimators are also consistent in presence of dependent competing risks.
Wilke, Ralf A., Lo, Simon M. S.
core   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Cholesterol and Hypertension Treatment Improve Coronary Risk Prediction but Not Time-Dependent Covariates or Competing Risks

Clinical Epidemiology, 2022
Isaac Subirana,1,2 Anna Camps-Vilaró,1,2 Roberto Elosua,2– 4 Jaume Marrugat,1,2 Helena Tizón-Marcos,2,5,6 Ivan Palomo,7 Irene R Dégano1– 3 1REGICOR Study Group, Department of Epidemiology and Public Health, Hospital del Mar Medical Research Institute ...
Subirana I, Camps-Vilaró A, Elosua R, Marrugat J, Tizón-Marcos H, Palomo I, Dégano IR   +6 more
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Competing risk and heterogeneity of treatment effect in clinical trials

Trials, 2008
It has been demonstrated that patients enrolled in clinical trials frequently have a large degree of variation in their baseline risk for the outcome of interest.
Alsheikh-Ali Alawi, Kent David M, Hayward Rodney A   +2 more
doaj   +1 more source