Results 51 to 60 of about 4,508,134 (250)

Study of Disease Progression and Relevant Risk Factors in Diabetic Foot Patients Using a Multistate Continuous-Time Markov Chain Model. [PDF]

PLoS ONE, 2016
The diabetic foot is a lifelong disease. The longer patients with diabetes and foot ulcers are observed, the higher the likelihood that they will develop comorbidities that adversely influence ulcer recurrence, amputation and survival (for example ...
Alexander Begun, Stephan Morbach, Gerhard Rümenapf, Andrea Icks   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A dependent competing risks model [PDF]

, 2018
The competing risks model considers the setting where subjects or units are exposed to multiple risks one of which may eventually cause the occurrence of the event, such as failure or recurrence or death.
Wang, Yiqing
core   +1 more source

Inference for Dependent Competing Risks with Partially Observed Causes from Bivariate Inverted Exponentiated Pareto Distribution Under Generalized Progressive Hybrid Censoring

Axioms
In this paper, inference under dependent competing risk data is considered with multiple causes of failure. We discuss both classical and Bayesian methods for estimating model parameters under the assumption that data are observed under generalized ...
Rani Kumari, Yogesh Mani Tripathi, Rajesh Kumar Sinha, Liang Wang   +3 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Competing Risks Data Analysis with High-dimensional Covariates: An Application in Bladder Cancer

Genomics, Proteomics & Bioinformatics, 2015
Analysis of microarray data is associated with the methodological problems of high dimension and small sample size. Various methods have been used for variable selection in high-dimension and small sample size cases with a single survival endpoint ...
Leili Tapak, Massoud Saidijam, Majid Sadeghifar, Jalal Poorolajal, Hossein Mahjub   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Gaussian Copula Regression Modeling for Marker Classification Metrics with Competing Risk Outcomes

International Journal of Mathematics and Mathematical Sciences
Decisions regarding competing risks are usually based on a continuous-valued marker toward predicting a cause-specific outcome. The classification power of a marker can be summarized using the time-dependent receiver operating characteristic curve and ...
Alejandro Román Vásquez, Gabriel Escarela, Hortensia Josefina Reyes-Cervantes, Gabriel Núñez-Antonio   +3 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Characterization of two competing risks models with Weibull risks [PDF]

, 2015
Competing risks are used to model life of systems with multiple failure modes where the observed failure is the minimum of the possible individual failures times.
Yáñez Canal, Sergio
core