Results 1 to 10 of about 205,153 (377)
STAT1 Gain-of-Function Mutations Cause High Total STAT1 Levels With Normal Dephosphorylation
Frontiers in Immunology, 2019 Signal transducer and activator of transcription (STAT1)1 gain of function (GOF) pathogenic variants have been associated with increased levels of phosphorylated STAT1 and STAT1-dependent cellular responses.
Ofer Zimmerman +14 more
doaj +2 more sources
LRRK2 dephosphorylation increases its ubiquitination [PDF]
Biochemical Journal, 2015 Activating mutations in the leucine rich repeat protein kinase 2 (LRRK2) gene are the most common cause of inherited Parkinson's disease (PD). LRRK2 is phosphorylated on a cluster of phosphosites including Ser910, Ser935, Ser955 and Ser973, which are dephosphorylated in several PD-related LRRK2 mutants (N1437H, R1441C/G, Y1699C and I2020T) linking the ...
Zhao, Jing +3 more
openaire +3 more sources
Dephosphorylation of the Retinoblastoma protein (Rb) inhibits cancer cell EMT via Zeb [PDF]
Cancer Biology & Therapy, 2016 The tumor suppressor Retinoblastoma (Rb) protein is highly phosphorylated in cancer cells largely due to the overexpression of cyclins or the loss of expression of cyclin dependent kinase inhibitors (cdki).
Jacklynn V. Egger +4 more
openalex +2 more sources
PECAM‐1 supports leukocyte diapedesis by tension‐dependent dephosphorylation of VE‐cadherin
EMBO Journal, 2021 Leukocyte extravasation is an essential step during the immune response and requires the destabilization of endothelial junctions. We have shown previously that this process depends in vivo on the dephosphorylation of VE‐cadherin‐Y731.
N. Arif +9 more
semanticscholar +1 more source
DTL-DephosSite: Deep Transfer Learning Based Approach to Predict Dephosphorylation Sites
Frontiers in Cell and Developmental Biology, 2021 Phosphorylation, which is mediated by protein kinases and opposed by protein phosphatases, is an important post-translational modification that regulates many cellular processes, including cellular metabolism, cell migration, and cell division.
Meenal Chaudhari +7 more
doaj +1 more source
Protein Tyrosine Phosphatases in Neuroblastoma: Emerging Roles as Biomarkers and Therapeutic Targets
Frontiers in Cell and Developmental Biology, 2021 Neuroblastoma is a type of cancer intimately related with early development and differentiation of neuroendocrine cells, and constitutes one of the pediatric cancers with higher incidence and mortality.
Caroline E. Nunes-Xavier +12 more
doaj +1 more source
RETRACTED: Ppm1b Negatively Regulates 3-Bromopyruvate Induced Necroptosis in Breast Cancer Cells
Frontiers in Oncology, 2021 Up to 30% of breast cancer mortality is caused by cancer relapse despite primary clinical treatments due to distant metastases. Further research focusing on breast cancer mechanisms are needed for deeper understanding of disease prognosis.
Yiming Sun +5 more
doaj +1 more source
Molecules, 2022 Considering that practically all reactions that involve nucleotides also involve metal ions, it is evident that the coordination chemistry of nucleotides and their derivatives is an essential corner stone of biological inorganic chemistry.
Astrid Sigel +2 more
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EMBO Journal, 2020 PP2A is an essential protein phosphatase that regulates most cellular processes through the formation of holoenzymes containing distinct regulatory B‐subunits. Only a limited number of PP2A‐regulated phosphorylation sites are known.
T. Kruse +14 more
semanticscholar +1 more source
Neural Regeneration Research, 2015 Subarachnoid hemorrhage is frequently associated with poor prognoses. Three different hemodynamic phases were identified during subarachnoid hemorrhage: oligemia, hyperemia, and vasospasm. Each phase is associated with brain metabolic changes.
Marcelo de Lima Oliveira +5 more
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