Results 91 to 100 of about 205,153 (377)

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Multiple functions of protein phosphatases in receptor tyrosine kinase signaling revealed by interactome analysis

Molecular & Cellular Oncology, 2017
To obtain a global picture of how protein phosphatases are involved in receptor tyrosine kinase (RTK) signaling, we mapped the RTK-phosphatase interactome. Analyses of selected interactions revealed detailed mechanisms of their actions.
Zhong Yao, Igor Stagljar
doaj   +1 more source

Autologous nerve graft repair of different degrees of sciatic nerve defect: stress and displacement at the anastomosis in a three-dimensional fnite element simulation model

Neural Regeneration Research, 2015
In the repair of peripheral nerve injury using autologous or synthetic nerve grafting, the magnitude of tensile forces at the anastomosis affects its response to physiological stress and the ultimate success of the treatment.
Cheng-dong Piao, Kun Yang, Peng Li, Min Luo   +3 more
doaj   +1 more source

Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs

Molecular & Cellular Proteomics, 2015
Entry into mitosis is driven by the coordinated phosphorylation of thousands of proteins. For the cell to complete mitosis and divide into two identical daughter cells it must regulate dephosphorylation of these proteins in a highly ordered, temporal ...
R. McCloy, B. Parker, Samuel Rogers, Rima Chaudhuri, V. Gayevskiy, Nolan J. Hoffman, Naveid A. Ali, D. Watkins, R. Daly, David E. James, T. Lorca, A. Castro, A. Burgess   +12 more
semanticscholar   +1 more source

Electrostatically gated membrane permeability in inorganic protocells [PDF]

, 2013
Although several strategies are now available to produce functional microcompartments analogous to primitive cell-like structures, little progress has been made in generating protocell constructs with self-controlled membrane permeability.
A Boker, A Dzieciol, A Pohorille, AB Subramaniam, AB Subramaniam, AD Dinsmore, B Städler, Bernard P. Binks, C Wu, D Lee, DS Williams, DY Wang, GJT Cooper, J-W Kim, Jonathan V. M. Weaver, JVM Weaver, JW Szostak, KL Thompson, M Li, Mei Li, MF Hsu, P Stano, P Stano, P Walde, Rachel L. Harbron, RK Shah, RL Harbron, S Koga, S Mann, Stephen Mann, W Martin   +30 more
core   +4 more sources

Procyanidin Capsules Combat ALF by Restoring Mitochondrial Homeostasis and Inhibiting Necroptosis via the PGAM5/DRP1/PINK1 Pathway

Advanced Science, EarlyView.
A biomimetic self‐assembly strategy, Procyanidin Capsules (PC‐Ca), has been developed, which has great stability, bioavailability, and liver‐targeting efficacy and modulates the KEAP1‐NRF2 axis to inhibit ROS formation and necroptosis, regulate mitochondrial homeostasis through the PGAM5/DRP1/PINK1 signaling pathway in thioacetamide (TAA)‐induced ALF ...
Qing Shi, Minmin Wu, Jinwei Zhong, Chao Chen, Zhuang Huang, Jingxuan Peng, Dong Yang, Xingjie Zan, Zhengfei Wang   +8 more
wiley   +1 more source

Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage

Cell Death and Disease, 2015
Inactivation of the retinoblastoma protein (Rb) has a key role in tumorigenesis. It is well established that Rb function is largely regulated by a dynamic balance of phosphorylation and dephosphorylation.
Y. Tong, H. Ying, R. Liu, Lan Li, J. Bergholz, Z. Xiao, Z. Xiao   +6 more
semanticscholar   +1 more source

PiTRAQ, a strategy to simultaneously correlate protein expression and phosphorylation stoichiometry between different samples: evaluation on different mass spectrometers [PDF]

, 2013
C
Colaert, Niklaas, Deforce, Dieter, Dhaenens, Maarten, Glibert, Pieter, Martens, Lennart, Meert, Paulien, Van Nieuwerburgh, Filip   +6 more
core   +1 more source

Spontaneous γH2AX Foci in Human Solid Tumor-Derived Cell Lines in Relation to p21WAF1 and WIP1 Expression. [PDF]

, 2015
Phosphorylation of H2AX on Ser139 (γH2AX) after exposure to ionizing radiation produces nuclear foci that are detectable by immunofluorescence microscopy.
Andrais, Bonnie, Mirzayans, Razmik, Murray, David, Scott, April, Wang, Ying W, Weiss, Robert H   +5 more
core   +2 more sources

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source