Results 111 to 120 of about 205,153 (377)

Enzymatic Dephosphorylation of C55-Isoprenylphosphate

Journal of Biological Chemistry, 1972
Abstract Membranes of Staphylococcus aureus contain an enzyme which catalyzes the dephosphorylation of C55-isoprenoid alcohol phosphate. Some properties of this enzyme are described. The possibility is suggested that this phosphatase and a previously described C55-isoprenoid alcohol phosphokinase represent a mechanism for regulation of cell wall ...
E, Willoughby, Y, Highasi, J L, Strominger   +2 more
openaire   +2 more sources

Dephosphorylation of 4EBP1/2 Induces Prenatal Neural Stem Cell Quiescence [PDF]

, 2023
Laura C. Geben, Asa A. Brockman, Mary‐Bronwen L. Chalkley, Serena R. Sweet, Julia E. Gallagher, Alexandra L. Scheuing, Richard B. Simerly, Kevin C. Ess, Jonathan M. Irish, Rebecca A. Ihrie   +9 more
openalex   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

RPRD1A and RPRD1B Are Human RNA Polymerase II C-Terminal Domain Scaffolds for Ser5 Dephosphorylation

Nature Structural &Molecular Biology, 2014
The RNA polymerase II (RNAPII) C-terminal domain (CTD) heptapeptide repeats (1-YSPTSPS-7) undergo dynamic phosphorylation and dephosphorylation during the transcription cycle to recruit factors that regulate transcription, RNA processing and chromatin ...
Z. Ni, Chao Xu, Xinghua Guo, Gerald O. Hunter, O. Kuznetsova, W. Tempel, E. Marcon, Guoqing Zhong, Hongbo Guo, W. Kuo, Joyce Li, Peter Young, Jonathan B. Olsen, Cuihong Wan, P. Loppnau, M. El Bakkouri, G. Senisterra, Hao He, Haiming Huang, S. Sidhu, A. Emili, Shona Murphy, A. Mosley, C. Arrowsmith, J. Min, J. Greenblatt   +25 more
semanticscholar   +1 more source

Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD‐L1 Expression and Acts as a Target to Enhance Anti‐PD‐1 Efficacy

Advanced Science, EarlyView.
A mutually exclusive screening system is established to identify negative regulators of highly plastic genes. Dual specificity phosphatase (DUSP9) is a novel negative regulatory molecule of PD‐L1 by dephosphorylating STAT3, and acts as a target molecule in combination with PD‐1 antibody for tumor immunotherapy and a new clinical biomarker for ...
Yuzhe Hu, Ling Tang, Zheng Kuang, Danyi Huang, Ting Li, Gaofei Yin, Yingyu Chen, Wei Guo, Wenling Han, Pingzhang Wang   +9 more
wiley   +1 more source

HPLC-MS/MS Analysis for Sphingosine 1-Phosphate after the Dephosphorylation by Hydrogen Fluoride

Separations
Sphingosine 1-phosphate (S1P) is a signaling lipid molecule involved in various cellular processes. It is important to develop a quantitative method for S1P to determine endogenous levels and to investigate its functions. As S1P is a tiny lipid component
Hee-Jung Kim, Seo-Hyeon Jung, Shokhid Gulyamov, Hyun-Gy Lee, Oybek Boyjigitov, Yong-Moon Lee   +5 more
doaj   +1 more source

Bibliometric profile of neurogenic bladder in the literature: a 20-year bibliometric analysis

Neural Regeneration Research, 2015
Neurogenic bladder is a dysfunction of the lower urinary tract caused by nervous system disorder. We investigated the trends in publication of articles under the topic "neurogenic bladder" using bibliometric analysis.
Yuan Gao, Bo Qu, Yan Shen, Xiao-jing Su, Xiao-yan Dong, Xue-mei Chen, Yu-hong Zhou, Hong-ying Pi   +7 more
doaj   +1 more source

Selective dephosphorylation by PP2A-B55 directs the meiosis I-meiosis II transition in oocytes

, 2021
S. Zachary Swartz, Hieu Nguyen, Brennan C McEwan, Mark E. Adamo, Iain M. Cheeseman, Arminja N. Kettenbach   +5 more
openalex   +1 more source

PP2A/B55 and Fcp1 Regulate Greatwall and Ensa Dephosphorylation during Mitotic Exit

PLoS Genetics, 2014
Entry into mitosis is triggered by activation of Cdk1 and inactivation of its counteracting phosphatase PP2A/B55. Greatwall kinase inactivates PP2A/B55 via its substrates Ensa and ARPP19.
Nadia Hé, C. Vesely, P. Vinod, Cory A. Ocasio, Nisha Peter, J. Gannon, A. Oliver, Bé La Nová K, H. Hochegger, Gregory P Copenhaver   +9 more
semanticscholar   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source