Results 121 to 130 of about 205,153 (377)

Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

Angewandte Chemie, EarlyView.
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu, Frederick Nguele Meke, Zheng Zhang, Aaron D. Krabill, Christine S. Muli, Brenson A. Jassim, Jiajun Dong, Quyen D. Nguyen, Yunpeng Bai, Jinyue Li, Yiming Miao, Bardia Asadi, Levi M. Johnson, Jinmin Miao, Darci J. Trader, W. Andy Tao, Zhong‐Yin Zhang   +16 more
wiley   +2 more sources

Multiple roles of mitochondrial autophagy receptor FUNDC1 in mitochondrial events and kidney disease

Frontiers in Cell and Developmental Biology
This article reviews the latest research progress on the role of mitochondrial autophagy receptor FUN14 domain containing 1 (FUNDC1) in mitochondrial events and kidney disease.
Kaiqing Li, Xue Xia, Ying Tong
doaj   +1 more source

Acupuncture and vitamin B12 injection for Bell′s palsy: no high-quality evidence exists

Neural Regeneration Research, 2015
OBJECTIVE: To assess the efficacy of acupuncture combined with vitamin B 12 acupoint injection versus acupuncture alone to reduce incomplete recovery in patients with Bell′s palsy.
Li-li Wang, Ling Guan, Peng-liang Hao, Jin-long Du, Meng-xue Zhang   +4 more
doaj   +1 more source

Flagellar oscillation: new vibes from beads [PDF]

, 1990
N/
Brokaw, Charles J.
core  

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

PP2Ac Regulates Autophagy via Mediating mTORC1 and ULK1 During Osteoclastogenesis in the Subchondral Bone of Osteoarthritis

Advanced Science
The molecular mechanism underlying abnormal osteoclastogenesis triggering subchondral bone remodeling in osteoarthritis (OA) is still unclear. Here, single‐cell and bulk transcriptomics sequencing analyses are performed on GEO datasets to identify key ...
Haifeng Zhang, Gaoran Ge, Wei Zhang, Houyi Sun, Xiaolong Liang, Yu Xia, Jiacheng Du, Zerui Wu, Jiaxiang Bai, Huilin Yang, Xing Yang, Jun Zhou, Yaozeng Xu, Dechun Geng   +13 more
doaj   +1 more source

MicroRNA-124 slows down the progression of Huntington′s disease by promoting neurogenesis in the striatum

Neural Regeneration Research, 2015
MicroRNA-124 contributes to neurogenesis through regulating its targets, but its expression both in the brain of Huntington′s disease mouse models and patients is decreased.
Tian Liu, Wooseok Im, Inhee Mook-Jung, Manho Kim   +3 more
doaj   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Targeting proteins for proteasomal degradation – a new function of Arabidopsis ABI1 protein phosphatase 2C

Frontiers in Plant Science, 2015
The ubiquitin/26S proteasome system (UPS) has been implicated in the regulation of many physiological processes including hormone signaling. The plant hormone abscisic acid (ABA) employs the UPS to control its own synthesis and signaling and to regulate ...
Agnieszka eLudwików
doaj   +1 more source

The human DEPhOsphorylation database DEPOD: a 2015 update

Nucleic Acids Res., 2014
Phosphatases are crucial enzymes in health and disease, but the knowledge of their biological roles is still limited. Identifying substrates continues to be a great challenge.
Guangyou Duan, Xun Li, M. Köhn
semanticscholar   +1 more source