Results 51 to 60 of about 205,153 (377)
Systems theory of Smad signaling
, 2006 Transforming Growth Factor-beta (TGF-beta) signalling is an important regulator of cellular growth and differentiation. The principal intracellular mediators of TGF-beta signalling are the Smad proteins, which upon TGF-beta stimulation accumulate in the ...
Alves +63 more
core +1 more source
Neural Regeneration Research, 2015 Thalidomide is an effective drug for the treatment of ankylosing spondylitis but might induce peripheral neuropathy. This major adverse reaction has attracted much concern.
Hong-xia Xue +5 more
doaj +1 more source
Dynamic Influence Networks for Rule-based Models [PDF]
, 2017 We introduce the Dynamic Influence Network (DIN), a novel visual analytics technique for representing and analyzing rule-based models of protein-protein interaction networks.
Boutillier, Pierre +6 more
core +5 more sources
Active zone stability: insights from fly neuromuscular junction
Neural Regeneration Research, 2015 The presynaptic active zone is a dynamic structure that orchestrates regulated release of neurotransmitters. Developmental and aging processes, and changes in neuronal network activity can all modulate the number, size and composition of active zone and ...
Xiaolin Tian, Chunlai Wu
doaj +1 more source
Molecules, 2020 Organophosphates (OPs) are esters of substituted phosphates, phosphonates or phosphoramidates that react with acetylcholinesterase (AChE) by initially transferring the organophosphityl group to a serine residue in the enzyme active site, concomitant with
Terrone L. Rosenberry
doaj +1 more source
Hepatitis B Virus Core Protein Dephosphorylation Occurs during Pregenomic RNA Encapsidation
Journal of Virology, 2018 Hepatitis B virus (HBV) core protein consists of an N-terminal assembly domain and a C-terminal domain (CTD) with seven conserved serines or threonines that are dynamically phosphorylated/dephosphorylated during the viral replication cycle ...
Qiong Zhao +7 more
semanticscholar +1 more source
Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development [PDF]
, 2009 Acquisition of epidermal barrier function occurs late in mouse gestation. Several days before birth a wave of barrier acquisition sweeps across murine fetal skin, converging on dorsal and ventral midlines.
Byrne, C +3 more
core +2 more sources
Neural Regeneration Research, 2015 Abnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer′s disease patients, resulting in neuronal death. This study investigated whether components extracted from the Chinese herbs epimedium herb, milkvetch root and ...
Xian-hui Dong +9 more
doaj +1 more source
Frontiers in Immunology, 2022 In this study, we investigated the effects of intestinal alkaline phosphatase (IAP) in controlled intestinal inflammation and alleviated associated insulin resistance (IR).
Chenzhe Gao +7 more
doaj +1 more source
An allosteric model of KaiC phosphorylation [PDF]
, 2007 In a recent series of ground-breaking experiments, Nakajima et al. [Science 308, 414-415 (2005)] showed that the three cyanobacterial clock proteins KaiA, KaiB, and KaiC are sufficient in vitro to generate circadian phosphorylation of KaiC.
Altena, Pim R. H. +3 more
core +3 more sources