Results 101 to 110 of about 6,149,007 (323)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
From desert to breadbasket…to desert again? A metabolic rift in the High Plains Aquifer
Journal of Political Ecology, 2014 The High Plains region of the U.S. is one of the most important agricultural regions in the world. Much agricultural production in this semi-arid region, however, depends on the consumption of nonrenewable groundwater from the High Plains Aquifer ...
Matthew R. Sanderson, R. Scott Frey
doaj +1 more source
Intermittent turbulence and turbulent structures in a linear magnetized plasma
, 2005 Strongly intermittent turbulence is observed in the shadow of a limiter in the Large Plasma Device (LAPD) at UCLA [W. Gekelman, H. Pfister, Z. Lucky, J. Bamber, D. Leneman, and J. Maggs, Rev. Sci. Inst. {\bfseries 62}, 2875 (1991)].
Carter, T. A.
core +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
High Performance Enhancement-Mode AlGaN/GaN MIS-HEMT with Selective Fluorine Treatment
Advances in Condensed Matter Physics, 2015 A novel enhancement-mode (E-mode) Metal-Insulator-Semiconductor- (MIS-) HEMT with selective fluorine ion (F−) treatment is proposed and its mechanism is investigated.
Chao Yang +5 more
doaj +1 more source
On ionisation effects and abundance ratios in damped Lyman-alpha systems
, 2000 The similarity between observed velocity structures of Al III and singly ionised species in damped Lyman-alpha systems (DLAs) suggests the presence of ionised gas in the regions where most metal absorption lines are formed.
Corinne Charbonnel +11 more
core +4 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Insights into Chemical Bonds for Eliminating the Depletion Region and Accelerating the Photo-Induced Charge Efficient Separation toward Ultrasensitive Photoelectrochemical Sensing. [PDF]
Biosensors (Basel), 2023 Wang S, Yu H, Ge S, Wang Y, Gao C, Yu J.
europepmc +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source