Results 81 to 90 of about 390,411 (306)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
On the size of the CO-depletion radius in the IRDC G351.77-0.51
, 2019 We present a study of the depletion of CO in the IRDC G351.77-0.51. Knowledge of the degree of CO-depletion provides information on the physical conditions occurring in the innermost and the densest regions of molecular clouds.
Sabatini, Giovanni (8170557) +2 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
How Depletion Layers Govern the Dynamic Plasmonic Response of In-doped CdO Nanocrystals
Doped metal oxide nanocrystals exhibit localized surface plasmon resonance that is widely tunable across the mid- to near-infrared region, making them useful for applications in optoelectronics, sensing, and photocatalysis.
Delia, Milliron +4 more
core +1 more source
A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]
, 2001 Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Darren Caldwell +9 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
From desert to breadbasket…to desert again? A metabolic rift in the High Plains Aquifer
Journal of Political Ecology, 2014 The High Plains region of the U.S. is one of the most important agricultural regions in the world. Much agricultural production in this semi-arid region, however, depends on the consumption of nonrenewable groundwater from the High Plains Aquifer ...
Matthew R. Sanderson, R. Scott Frey
doaj +1 more source
Sensing and Bio-Sensing Research, 2016 Subthreshold region provides optimal sensitivity for nanowire biosensor. In this paper, sensitivity analysis of nanowire biosensor operating in partially depleted and fully depleted mode of subthreshold region is presented. The analysis is based on analytical radial electrostatic potential functions derived by solving Poisson's equation inside the ...
Manisree Majumder +4 more
openaire +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
High Performance Enhancement-Mode AlGaN/GaN MIS-HEMT with Selective Fluorine Treatment
Advances in Condensed Matter Physics, 2015 A novel enhancement-mode (E-mode) Metal-Insulator-Semiconductor- (MIS-) HEMT with selective fluorine ion (F−) treatment is proposed and its mechanism is investigated.
Chao Yang +5 more
doaj +1 more source