Results 101 to 110 of about 390,411 (306)
Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin
Neurobiology of Disease, 2006 Huntington's disease is a neurodegenerative disease caused by an expanded polyglutamine stretch within the huntingtin protein. Transfection of mutant huntingtin causes cell toxicity and depletion of CREB binding protein (CBP) or its recruitment into ...
Haibing Jiang +7 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Metals, 2017 This work investigated the isothermal holding time dependence of the densification, microstructure, weight loss, and tensile properties of Fe-Mn-Si powder compacts.
Zhigang Xu +5 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
, 2011 Depletion interactions in correlated fluids are investigated both theoretically and experimentally. A formally exact derivation of a general expression for depletion interactions is presented and then specialized to the case of critical correlations in ...
COLOMBO, JADER +3 more
core +2 more sources
A Dense Molecular Ringlike Structure in Gaseous CO Depletion Region G34.74−0.12
The Astrophysical Journal LettersWe report the discovery of a dense molecular ringlike structure in a dense (10 ^5 cm ^−3 ), cold (parsec-scale CO depletion at a factor of 5), and young (10 ^4 yr) star-forming region G34.74−0.12, revealed by C ^18 O (2−1), HNC (1−0), and N _2 H ^+ (1−0)
Shuting Lin +16 more
doaj +1 more source
Remote SensingWe present new insights into post-sunrise ionospheric irregularities in Southeast Asia during the intense geomagnetic storm of 19–20 April 2024. By utilizing Total Electron Content (TEC) and Rate of TEC Change Index (ROTI) maps, along with ionosondes, we
Prayitno Abadi +14 more
doaj +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Monitoring CD27 expression to evaluate Mycobacterium tuberculosis activity in HIV-1 infected individuals in vivo. [PDF]
, 2011 The level of bacterial activity is only poorly defined during asymptomatic Mycobacterium tuberculosis (MTB) infection. The objective was to study the capacity of a new biomarker, the expression of the T cell maturation marker CD27 on MTB-specific CD4 T ...
Geldmacher Christof +31 more
core +1 more source